SPOP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5303888	0.65	14/20
SCHEMBL5332145	0.63	12/20
SCHEMBL5332149	0.63	12/20
SCHEMBL5252334	0.50	12/20
SCHEMBL5794628	0.49	12/20
SCHEMBL5285671	0.58	11/20
SCHEMBL7769796	0.56	11/20
SCHEMBL1131847	0.52	11/20
SCHEMBL1131848	0.52	11/20
SCHEMBL5284761	0.52	11/20
SCHEMBL5592457	0.52	11/20
SCHEMBL7770365	0.52	11/20
SCHEMBL7770536	0.47	11/20
SCHEMBL8169558	0.47	11/20
SCHEMBL5500594	0.47	11/20
SCHEMBL5500601	0.47	11/20
SCHEMBL1902817	0.49	10/20
SCHEMBL3294983	0.49	10/20
SCHEMBL2615017	0.47	10/20
SCHEMBL6677262	0.46	10/20

Clinical trials — most relevant to SPOP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men	PHASE3	ACTIVE_NOT_RECRUITING
Signal TrAnsduction Pathway Activity Analysis in OVarian cancER	PHASE2/PHASE3	RECRUITING
Proteome-based Immunotherapy of Brain Metastases From Breast Cancer	PHASE2/PHASE3	UNKNOWN
CJNJ-67652000 and Prednisone for Treatment of Metastatic Castration-Resistant Prostate Cancer and SPOP Gene Mutations	PHASE2	ACTIVE_NOT_RECRUITING
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility	nan	COMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI	nan	RECRUITING
Post Market Surveillance & Post Market Clinical Follow up, International, Medical Registry to Confirm the Safety and the Performance of the Anecova Intra Uterine Culture Device	nan	WITHDRAWN
Prospective Genetic Study in Patients With Ovarian Insufficiency	nan	UNKNOWN
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Proteomic-Based Profiling of Lymphomas: Chromatin Proteomics; Composition and Modification of Histone and Non-Histone Chromosomal Proteins	nan	COMPLETED
Importance of the Microtubule Cytoskeleton in Oocyte Competence	nan	COMPLETED
X-Chromosome Inactivation Status and Premature Ovarian Failure	nan	COMPLETED
Tobacco and Sperm Genome: Effects of Smoking Cessation	nan	COMPLETED
Premature Ovarian Failure (Genetic and Physiopathologic Analysis)	nan	UNKNOWN
Genetic Studies Spermatogenic Failure	nan	COMPLETED
Study to Verify the Efficacy of a Product Containing 125 mg of TetraSOD® for the Treatment of Male Infertility	nan	RECRUITING
Study of Sperm Molecular Factors Implicated in Male Fertility	nan	COMPLETED
Efficacy of Oocyte Activation With Two Types of Ca2+ Ionophore.	nan	UNKNOWN
Assessment of TetraSOD® Efficacy to Improve Semen Parameters in Men With Idiopathic Infertility	nan	COMPLETED
Identification of New Prognostic Markers for Breast Cancer.	nan	RECRUITING
Outcome of Using Sperm Bound to the Zona Pellucida of Immature Oocytes for Intracytoplasmic Sperm Injection (ICSI)	nan	COMPLETED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
Genetic Causes of Male Infertility	nan	COMPLETED
Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)	nan	RECRUITING
A Study of Multilocus Methylation Abnormalities in Subjects With Imprinting Disorders	nan	NOT_YET_RECRUITING
Prostate Cancer Prevention Clinic for Men With Risk of Familial Prostate Cancer	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a SPOP binder may also engage these)

Protein	Name	Similarity
Q5NVK7	—	1.000	Q5NVK7 →
Q6ZWS8	—	1.000	Q6ZWS8 →
Q6P8B3	—	1.000	Q6P8B3 →
Q7ZX06	—	1.000	Q7ZX06 →
Q7T330	—	1.000	Q7T330 →
Q0VCW1	—	1.000	Q0VCW1 →
Q0IHH9	—	1.000	Q0IHH9 →
Q5BL35	—	0.947	Q5BL35 →
Q6IQ16	—	0.942	Q6IQ16 →
Q2M2N2	—	0.924	Q2M2N2 →
A0JMG1	—	0.919	A0JMG1 →
PRKG1	cGMP-dependent protein kinase 1	0.899	landscape →
P00516	—	0.898	P00516 →
P0C605	—	0.893	P0C605 →
Q91ZH7	—	0.891	Q91ZH7 →
Q0VC00	—	0.890	Q0VC00 →
O77676	—	0.888	O77676 →
Q56JV3	—	0.888	Q56JV3 →
RHEB	GTP-binding protein Rheb	0.886	landscape →
MTAP	S-methyl-5'-thioadenosine phosphorylase	0.885	landscape →
Q921J2	—	0.885	Q921J2 →
Q62639	—	0.884	Q62639 →
RFC2	Replication factor C subunit 2	0.884	landscape →
Q3MHL3	—	0.881	Q3MHL3 →
Q9W7I5	—	0.881	Q9W7I5 →
Q5RF92	—	0.881	Q5RF92 →
F6RQL9	—	0.880	F6RQL9 →
Q5M7K4	—	0.880	Q5M7K4 →
P31321	—	0.880	P31321 →
P53033	—	0.879	P53033 →