Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.84 |
| ▸ | ATM | Q13315 | 1/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1946258 | 0.99 | L3MBTL1 (0.86) | L3MBTL1ATMKDM4EALDH1A1TDP1 | |
| Cadaverine Tartrate SCHEMBL27494555 | 0.92 | L3MBTL1 (0.76) | L3MBTL1ATMKDM4EALDH1A1TDP1 | |
| SCHEMBL14022760 | 0.91 | L3MBTL1 (0.74) | L3MBTL1ATMKDM4EALDH1A1TDP1 | |
| SCHEMBL1545229 | 0.91 | L3MBTL1 (0.74) | L3MBTL1ATMKDM4EALDH1A1TDP1 | |
| SCHEMBL8263564 | 0.91 | L3MBTL1 (0.74) | L3MBTL1ATMKDM4EALDH1A1TDP1 | |
| SCHEMBL8250801 | 0.89 | ALDH1A1 (0.80) | L3MBTL1ATMKDM4EALDH1A1TDP1 | |
| SCHEMBL3317577 | 0.89 | L3MBTL1 (0.71) | L3MBTL1ATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4850083 | 0.88 | ALDH1A1 (0.78) | L3MBTL1ATMKDM4EALDH1A1TDP1 | |
| SCHEMBL6183167 | 0.87 | L3MBTL1 (0.69) | L3MBTL1ATMKDM4EALDH1A1TDP1 | |
| SCHEMBL10016602 | 0.87 | KDM4E (1.00) | L3MBTL1ATMKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4950674-A | Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-21 | — | — | US | disclosed |