SCHEMBL104627

SCHEMBL104627

O=C(O)CNCc1c[nH]c(=S)[nH]c1=O

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
KDM3B Q7LBC6 1/20 0.47
ALDH1A1 P00352 1/20 0.36
PNP P00491 3/20 0.34
MEN1 O00255 1/20 0.32
GAA P10253 1/20 0.32
PPARG P37231 1/20 0.31
NCOA2 Q15596 1/20 0.31
NCOA1 Q15788 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
NCOA3 Q9Y6Q9 1/20 0.31
SLC22A4 Q9H015 1/20 0.30
PDCD1 Q15116 1/20 0.30
CD274 Q9NZQ7 1/20 0.30
PARP1 P09874 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5-Bromouracil SCHEMBL639925 0.87 KMT2A (0.39) KMT2ATDP1KDM3BALDH1A1MEN1
SCHEMBL9109566 0.85 KMT2A (0.46) KMT2ATDP1KDM3BALDH1A1PNP
SCHEMBL101944 0.84 LMNA (0.41) GAA
SCHEMBL18653592 0.82 KMT2A (0.37) KMT2ATDP1KDM3BPARP1
SCHEMBL1227831 0.78 KMT2A (0.62) KMT2ATDP1KDM3BALDH1A1MEN1
SCHEMBL29638100 0.75 KMT2A (0.42) KMT2ATDP1KDM3BPNP
SCHEMBL29100444 0.75 KMT2A (0.45) KMT2ATDP1KDM3BPNP
SCHEMBL15798435 0.74 KMT2A (0.44) KMT2ATDP1KDM3BPNP
SCHEMBL19645927 0.73 KMT2A (0.46) KMT2ATDP1KDM3BALDH1A1MEN1
SCHEMBL7206108 0.73 CYP3A4 (0.33) PNPGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6570 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12577554-B2 Methods for purification of messenger RNA TRANSLATE BIO, INC. (US) 2026-03-17 US claimed
US-12569572-B2 Messenger RNA therapy for the treatment of Friedreich's ataxia TRANSLATE BIO, INC. (US) 2026-03-10 US claimed
US-12552858-B2 Methods and compositions for delivering mRNA coded antibodies TRANSLATE BIO, INC. (US) 2026-02-17 US claimed
US-20250257360-A1 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER UNIV OKLAHOMA (US) 2025-08-14 US claimed
WO-2025137576-A1 MULTIPLE SPECIFIC ANTIBODIES TARGETING CD19, CD20, AND/OR CD47 NUTCRACKER THERAPEUTICS, INC. (US) 2025-06-26 WO claimed
EP-4504945-A2 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER The Board of Regents of the University of Oklahoma (US) 2025-02-12 EP claimed
US-12146139-B2 Oligonucleotide interference treatments of prostate cancer THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2024-11-19 US claimed
WO-2023196944-A2 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2023-10-12 WO claimed
US-20220372158-A1 RNA-CODED ANTIBODY CUREVAC AG (DE) 2022-11-24 US claimed
EP-4058152-A1 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER The Board of Regents of the University of Oklahoma (US) 2022-09-21 EP claimed
WO-2014152909-A1 ALTERATION OF GENE EXPRESSION BY SYNTHETIC piRNAs AND BY ALTERATION OF piRNA FUNCTION IBIS BIOSCIENCES, INC. (US) 2014-09-25 WO claimed
WO-2014093924-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2014-06-19 WO claimed
WO-2013158046-A1 RNAI-BASED THERAPIES FOR CARDIOMYOPATHIES, MUSCULAR DYSTROPHIES AND LAMINOPATHIES AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2013-10-24 WO claimed
US-20130195867-A1 RNA-CODED ANTIBODY CUREVAC GMBH (DE) 2013-08-01 US claimed
US-20100189729-A1 RNA-CODED ANTIBODY CURVAC GMBH (DE) 2010-07-29 US claimed
EP-2101823-A2 RNA-CODED ANTIBODY Curevac GmbH (DE) 2009-09-23 EP claimed
WO-2008083949-A2 RNA-CODED ANTIBODY CUREVAC GMBH (DE) 2008-07-17 WO claimed
JP-2002531470-A 2002-09-24 JP claimed
EP-1163374-A2 ARRAYS OF ORGANIC COMPOUNDS ATTACHED TO SURFACES Syntrix Biochip, Inc. (US) 2001-12-19 EP claimed
WO-2000033084-A2 ARRAYS OF ORGANIC COMPOUNDS ATTACHED TO SURFACES SYNTRIX BIOCHIP, INC. (US) 2000-06-08 WO claimed