Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | HTR2B | P41595 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10462765 | 0.83 | HTR1A (0.34) | SIGMAR1SLC6A2SLC6A4SLC6A3HTR2A | |
| Fumaric Acid SCHEMBL10462766 | 0.76 | HRH2 (0.51) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL10463903 | 0.71 | MAOA (0.50) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| Hydrochloric Acid SCHEMBL10463419 | 0.70 | MAOA (0.48) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL31808827 | 0.59 | DRD3 (0.54) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL2248107 | 0.59 | DRD3 (0.54) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL11872516 | 0.56 | HPGD (0.42) | NFKB1NFKB2RELA | |
| SCHEMBL8118995 | 0.56 | HRH2 (0.48) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL8816329 | 0.56 | MAOA (0.65) | — | |
| SCHEMBL9563141 | 0.56 | ERCC5 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904688-A | Tricyclic amine derivatives | AKZO N.V. (NL) | 1990-02-27 | — | — | US | disclosed |
| EP-0332246-A1 | Tricyclic amine derivatives | AKZO N.V. (NL) | 1989-09-13 | — | — | EP | disclosed |