Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 11/20 | 1.00 |
| ▸ | CRBN | Q96SW2 | 5/20 | 1.00 |
| ▸ | TBXAS1 | P24557 | 5/20 | 1.00 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30800784 | 0.89 | CRBN (1.00) | PDE3BPDE3ACRBNTBXAS1TNIK | |
| SCHEMBL20777317 | 0.89 | CRBN (1.00) | PDE3BPDE3ACRBNTBXAS1TNIK | |
| SCHEMBL9088237 | 0.80 | PDE3B (0.66) | PDE3BPDE3ACRBNTBXAS1LMNA | |
| SCHEMBL21247640 | 0.79 | TNIK (1.00) | PDE3BPDE3ACRBNTBXAS1TNIK | |
| SCHEMBL9700754 | 0.78 | PDE3B (0.64) | PDE3BPDE3ACRBNTBXAS1TNIK | |
| SCHEMBL9700740 | 0.78 | PDE3B (0.64) | PDE3BPDE3ACRBNTBXAS1TNIK | |
| SCHEMBL20772789 | 0.77 | CRBN (1.00) | PDE3BPDE3ACRBNTBXAS1TNIK | |
| SCHEMBL30800732 | 0.77 | CRBN (1.00) | PDE3BPDE3ACRBNTBXAS1TNIK | |
| SCHEMBL28274911 | 0.76 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1LMNA | |
| SCHEMBL10464755 | 0.76 | TBXAS1 (1.00) | PDE3BPDE3ACRBNTBXAS1TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250084055-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2025-03-13 | — | — | US | claimed |
| EP-3679028-A1 | DIHYDROQUINOLINONES | C4 Therapeutics, Inc. (US) | 2020-07-15 | — | — | EP | claimed |
| CN-111278816-A | Dihydroquinolinones | C4医药公司 | 2020-06-12 | — | — | CN | claimed |
| WO-2019043208-A1 | DIHYDROQUINOLINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2019-03-07 | — | — | WO | claimed |
| US-20250084055-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2025-03-13 | — | — | US | disclosed |
| US-12091397-B2 | Dihydroquinolinones for medical treatment | C4 THERAPEUTICS, INC. | 2024-09-17 | — | — | US | disclosed |
| CN-111278816-B | Dihydro quinolinones | C4医药公司 | 2024-03-15 | — | — | CN | disclosed |
| US-20230192643-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230192643-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230192643-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | US | disclosed |
| US-11401256-B2 | Dihydroquinolinones for medical treatment | C4 THERAPEUTICS, INC. (US) | 2022-08-02 | — | — | US | disclosed |
| EP-3679028-A1 | DIHYDROQUINOLINONES | C4 Therapeutics, Inc. (US) | 2020-07-15 | — | — | EP | disclosed |
| US-20200207733-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2020-07-02 | — | — | US | disclosed |
| US-20200207733-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2020-07-02 | — | — | US | disclosed |
| CN-111278816-A | Dihydroquinolinones | C4医药公司 | 2020-06-12 | — | — | CN | disclosed |
| WO-2019043208-A1 | DIHYDROQUINOLINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2019-03-07 | — | — | WO | disclosed |
| WO-2019043208-A1 | DIHYDROQUINOLINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2019-03-07 | — | — | WO | disclosed |
| US-4921862-A | Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1990-05-01 | — | — | US | disclosed |
| US-4792561-A | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12091397-B2 | Dihydroquinolinones for medical treatment | CRBN, RBX1, ADRM1 | PDE3B 4238/4885PDE3A 4254/4885CRBN 1/4885 |
| US-20230192643-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | CRBN, RBX1, ADRM1 | PDE3B 4238/4885PDE3A 4254/4885CRBN 1/4885 |
| US-20250084055-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | CRBN, RBX1, ADRM1 | PDE3B 4238/4885PDE3A 4254/4885CRBN 1/4885 |
| US-20200207733-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | CRBN, RBX1, ADRM1 | PDE3B 4238/4885PDE3A 4254/4885CRBN 1/4885 |
| US-11401256-B2 | Dihydroquinolinones for medical treatment | CRBN, RBX1, ADRM1 | PDE3B 4238/4885PDE3A 4254/4885CRBN 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.