Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10465899 | 0.88 | NPC1 (0.59) | MAPTMEN1KMT2ASMN1; SMN2ROCK1 | |
| SCHEMBL10465717 | 0.86 | MAPT (0.49) | MAPTMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL10465812 | 0.85 | MAPT (0.66) | MAPTMEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL10464664 | 0.83 | L3MBTL1 (0.62) | MAPTMEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL10465400 | 0.80 | MAPK1 (0.60) | MAPTMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL353310 | 0.79 | ROCK1 (0.59) | MAPTSMN1; SMN2ROCK1ALDH1A1HPGD | |
| SCHEMBL10465546 | 0.79 | ROCK2 (0.54) | MAPTMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL10465774 | 0.78 | ALDH1A1 (0.49) | MAPTMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL10465715 | 0.78 | CYP1A2 (0.54) | MAPTMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL10465399 | 0.78 | L3MBTL1 (0.54) | MAPTMEN1KMT2ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |