Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10466115 | 0.82 | — | — | |
| SCHEMBL172489 | 0.76 | MAPT (0.48) | NPC1RAB9AKDM4EGAAMAPT | |
| SCHEMBL11413359 | 0.75 | — | — | |
| SCHEMBL6454577 | 0.75 | ALDH1A1 (0.38) | KDM4ESMN1; SMN2 | |
| SCHEMBL1269615 | 0.74 | GAA (0.58) | NPC1RAB9AKDM4EGAAMAPT | |
| SCHEMBL10465750 | 0.73 | ALDH1A1 (0.32) | NPC1RAB9AGAA | |
| SCHEMBL18683261 | 0.72 | ALDH1A1 (0.41) | NPC1RAB9AKDM4EGAAMAPT | |
| SCHEMBL7295754 | 0.72 | ALDH1A1 (0.50) | NPC1RAB9AKDM4EGAAMAPT | |
| SCHEMBL12881975 | 0.72 | APP (0.40) | GAAMAPTTHRBRECQL | |
| SCHEMBL69853 | 0.72 | CA2 (0.40) | NPC1RAB9AKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |