Known targets — ChEMBL curated mechanism
82298078230507823050882308198230924823093782309578231029823151182323108232678823291582336198233620823362182338238234154823440782344088234840823547582360878236088823610082369748237447823761882377958238085823808682383438238380823840482399208240195
The experimentally established mechanism targets of Piperonyl Butoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperonyl Butoxide SCHEMBL29386186 | 0.98 | CYP3A4 (1.00) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL5490 | 0.98 | CYP3A4 (1.00) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL1517385 | 0.98 | CYP3A4 (1.00) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| SCHEMBL9958244 | 0.98 | CYP3A4 (1.00) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL6561910 | 0.98 | CYP3A4 (1.00) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL11895741 | 0.97 | CYP3A4 (0.97) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL16105717 | 0.97 | CYP3A4 (0.97) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL4809313 | 0.97 | CYP3A4 (0.97) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL2588661 | 0.97 | CYP3A4 (0.97) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL1654891 | 0.97 | CYP3A4 (0.97) | CYP3A4ALDH1A1TSHRHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025243002-A1 | FLUORINATION PROCESS | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2025-11-27 | — | — | WO | disclosed |
| EP-2241546-B1 | PROCESS FOR PRODUCTION OF BENZALDEHYDE COMPOUND | SUMITOMO CHEMICAL CO (JP) | 2017-10-04 | — | — | EP | disclosed |
| EP-2426098-B1 | PROCESS FOR PRODUCING POLYHYDRIC PHENOL | MITSUI CHEMICALS INC (JP) | 2015-01-21 | — | — | EP | disclosed |
| US-8604253-B2 | Method for producing polyhydric phenol | MITSUI CHEMICALS, INC. (JP) | 2013-12-10 | — | — | US | disclosed |
| US-8258349-B2 | Process for production of benzaldehyde compound | SUITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-09-04 | — | — | US | disclosed |
| EP-2426098-A1 | PROCESS FOR PRODUCING POLYHYDRIC PHENOL | Mitsui Chemicals, Inc. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20120046498-A1 | METHOD FOR PRODUCING POLYHYDRIC PHENOL | MITSUI CHEMICALS, INC. (JP) | 2012-02-23 | — | — | US | disclosed |
| US-20100292513-A1 | PROCESS FOR PRODUCTION OF BENZALDEHYDE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-11-18 | — | — | US | disclosed |
| EP-2241546-A1 | PROCESS FOR PRODUCTION OF BENZALDEHYDE COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| EP-1806333-A1 | A method for manufacturing dialkyl carbonate | GENERAL ELECTRIC COMPANY (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1299341-B1 | A METHOD FOR MANUFACTURING DIALKYL CARBONATE | GEN ELECTRIC (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1299341-A2 | A METHOD FOR MANUFACTURING DIALKYL CARBONATE | GENERAL ELECTRIC COMPANY (US) | 2003-04-09 | — | — | EP | disclosed |
| US-6458914-B2 | REACTING CARBON MONOXIDE, OXYGEN AND ALCOHOL IN THE PRESENCE OF A CATALYST PRODUCED BY REACTING TOGETHER AND INCLUDING A CUPRIC HALIDE AND AN ALKOXIDE COMPOUND OF A GROUP III THROUGH VII METAL; EFFICIENCY; ANTIFOULING AGENTS | GENERAL ELECTRIC COMPANY | 2002-10-01 | — | — | US | disclosed |
| EP-1189870-A1 | METHOD FOR MANUFACTURING DIALKYL CARBONATE | GENERAL ELECTRIC COMPANY (US) | 2002-03-27 | — | — | EP | disclosed |
| US-20020007087-A1 | Method for manufacturing dialkyl carbonate | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2002-01-17 | — | — | US | disclosed |
| WO-2002000596-A2 | A METHOD FOR MANUFACTURING DIALKYL CARBONATE | GENERAL ELECTRIC COMPANY (US) | 2002-01-03 | — | — | WO | disclosed |
| US-6258923-B1 | REACTING CARBON MONOXIDE, OXYGEN AND ALCOHOL | GENERAL ELECTRIC COMPANY | 2001-07-10 | — | — | US | disclosed |
| WO-2000076950-A1 | METHOD FOR MANUFACTURING DIALKYL CARBONATE | GENERAL ELECTRIC COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292513-A1 | PROCESS FOR PRODUCTION OF BENZALDEHYDE COMPOUND | CBR3, ADH5, ALDH1A1 | CYP3A4 102/4885ALDH1A1 3/4885TSHR 3370/4885 |
| US-20120046498-A1 | METHOD FOR PRODUCING POLYHYDRIC PHENOL | HPD, HAAO, SCO2 | CYP3A4 462/4885ALDH1A1 969/4885TSHR 2762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.