Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10468097 | 1.00 | HSD11B1 (0.40) | HSD11B1CCR2PTGS2MEN1KMT2A | |
| SCHEMBL10468088 | 1.00 | HSD11B1 (0.40) | HSD11B1CCR2PTGS2MEN1KMT2A | |
| SCHEMBL10470144 | 1.00 | HSD11B1 (0.40) | HSD11B1CCR2PTGS2MEN1KMT2A | |
| SCHEMBL10467434 | 0.85 | LMNA (0.41) | CCR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL10467989 | 0.85 | LMNA (0.41) | CCR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL10467452 | 0.85 | LMNA (0.41) | CCR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL10467712 | 0.85 | LMNA (0.41) | CCR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL10467453 | 0.85 | LMNA (0.41) | CCR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL10467674 | 0.85 | LMNA (0.41) | CCR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL10467987 | 0.85 | LMNA (0.41) | CCR2MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4927826-A | Cycloproylpropenamides useful as platelet activing factor (PAF) antagonists | HOFFMAN-LA ROCHE INC. (US) | 1990-05-22 | — | — | US | disclosed |
| US-4786646-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 1988-11-22 | — | — | US | disclosed |