Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10467434 | 1.00 | LMNA (0.41) | LMNAALDH1A1HDAC3TNKSHDAC4 | |
| SCHEMBL10467674 | 1.00 | LMNA (0.41) | LMNAALDH1A1HDAC3TNKSHDAC4 | |
| SCHEMBL10467987 | 1.00 | LMNA (0.41) | LMNAALDH1A1HDAC3TNKSHDAC4 | |
| SCHEMBL10467989 | 1.00 | LMNA (0.41) | LMNAALDH1A1HDAC3TNKSHDAC4 | |
| SCHEMBL10467453 | 1.00 | LMNA (0.41) | LMNAALDH1A1HDAC3TNKSHDAC4 | |
| SCHEMBL10467452 | 1.00 | LMNA (0.41) | LMNAALDH1A1HDAC3TNKSHDAC4 | |
| SCHEMBL10467576 | 0.85 | HSD11B1 (0.40) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL10468097 | 0.85 | HSD11B1 (0.40) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL10470144 | 0.85 | HSD11B1 (0.40) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL10468088 | 0.85 | HSD11B1 (0.40) | LMNAALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4927826-A | Cycloproylpropenamides useful as platelet activing factor (PAF) antagonists | HOFFMAN-LA ROCHE INC. (US) | 1990-05-22 | — | — | US | disclosed |
| US-4786646-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 1988-11-22 | — | — | US | disclosed |