Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 7/20 | 0.58 |
| ▸ | HTR6 | P50406 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PPME1 | Q9Y570 | 3/20 | 0.42 |
| ▸ | APEH | P13798 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.41 |
| ▸ | HTR1B | P28222 | 3/20 | 0.41 |
| ▸ | HTR1F | P30939 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10466733 | 0.86 | RAPGEF4 (0.76) | RAPGEF4HTR6MEN1ALDH1A1LMNA | |
| SCHEMBL24282438 | 0.81 | PPARG (0.49) | RAPGEF4HTR6MEN1ALDH1A1LMNA | |
| SCHEMBL9902100 | 0.79 | RAPGEF4 (0.53) | RAPGEF4HTR6MEN1ALDH1A1LMNA | |
| SCHEMBL27577523 | 0.79 | RAPGEF4 (0.53) | RAPGEF4HTR6MEN1ALDH1A1LMNA | |
| SCHEMBL14113374 | 0.79 | RAPGEF4 (0.53) | RAPGEF4HTR6MEN1ALDH1A1LMNA | |
| SCHEMBL18086719 | 0.75 | RAPGEF4 (0.43) | RAPGEF4HTR6MEN1ALDH1A1LMNA | |
| SCHEMBL15175998 | 0.73 | RAPGEF4 (1.00) | RAPGEF4HTR6ALDH1A1TSHRHTT | |
| SCHEMBL6259796 | 0.73 | RAPGEF4 (0.70) | RAPGEF4HTR6HTTL3MBTL1 | |
| SCHEMBL28324390 | 0.73 | RAPGEF4 (0.70) | RAPGEF4HTR6HTTPTGDR2L3MBTL1 | |
| SCHEMBL1599348 | 0.73 | HTR6 (0.50) | RAPGEF4HTR6MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4935440-A | ANALGESICS, ANTIPYRETICS | SYNTEX (U.S.A.) INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4833155-A | SKIN DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1989-05-23 | — | — | US | disclosed |
| EP-0269981-A1 | 3-[alpha-(3,5-di-t-butyl-4-hydroxyphenyl)-alkanoyl]pyrroles, their de-oxy analogs, and therapeutic uses thereof | SYNTEX (U.S.A.) INC. (US) | 1988-06-08 | — | — | EP | disclosed |