Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PPME1 | Q9Y570 | 2/20 | 0.41 |
| ▸ | APEH | P13798 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10466733 | 0.81 | RAPGEF4 (0.76) | RAPGEF4TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL10467848 | 0.79 | RAPGEF4 (0.58) | RAPGEF4TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL9902100 | 0.78 | RAPGEF4 (0.53) | RAPGEF4TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL27577523 | 0.78 | RAPGEF4 (0.53) | RAPGEF4TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL10176180 | 0.76 | HTR6 (0.47) | RAPGEF4TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL18086719 | 0.74 | RAPGEF4 (0.43) | RAPGEF4TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL24282438 | 0.73 | PPARG (0.49) | RAPGEF4TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL1599348 | 0.72 | HTR6 (0.50) | RAPGEF4TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL27648508 | 0.71 | PPME1 (0.44) | RAPGEF4TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL27648506 | 0.71 | PPME1 (0.44) | RAPGEF4TSHRALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673586-B2 | Compounds that interact with kinases | ALCHEMIA LIMITED (AU) | 2014-03-18 | — | — | US | disclosed |
| US-20130011852-A1 | COMPOUNDS THAT INTERACT WITH KINASES | ALCHEMIA LIMITED (AU) | 2013-01-10 | — | — | US | disclosed |
| US-20130011852-A1 | COMPOUNDS THAT INTERACT WITH KINASES | ALCHEMIA LIMITED (AU) | 2013-01-10 | — | — | US | disclosed |
| US-20080176815-A1 | Compounds that interact with kinases | ALCHEMIA LIMITED (AU) | 2008-07-24 | — | — | US | disclosed |
| US-20080176815-A1 | Compounds that interact with kinases | ALCHEMIA LIMITED (AU) | 2008-07-24 | — | — | US | disclosed |
| US-7291623-B2 | Compounds that interact with kinases | ALCHEMIA LIMITED (AU) | 2007-11-06 | — | — | US | disclosed |
| US-7291623-B2 | Compounds that interact with kinases | ALCHEMIA LIMITED (AU) | 2007-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176815-A1 | Compounds that interact with kinases | MAP3K6, MAP3K20, MAP4K2 | RAPGEF4 1923/4885TSHR 3479/4885ALDH1A1 3275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.