Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10469117 | 0.83 | HTR1A (0.45) | HTR1ADRD2HTR2APDE3BPDE3A | |
| SCHEMBL10468200 | 0.80 | HTR1A (0.42) | HTR1ADRD2HTR2APDE3BPDE3A | |
| SCHEMBL10467832 | 0.80 | ALDH1A1 (0.43) | HTR1ADRD2HTR2APDE3BPDE3A | |
| SCHEMBL10467997 | 0.80 | ALDH1A1 (0.42) | HTR1ADRD2HTR2APDE3BPDE3A | |
| SCHEMBL10467949 | 0.72 | HRH4 (0.46) | HTR1ADRD2HTR2APDE3BPDE3A | |
| SCHEMBL1031402 | 0.71 | ALDH1A1 (0.55) | HTR1ADRD2HTR2APDE3BPDE3A | |
| SCHEMBL9219349 | 0.71 | HTR1A (0.42) | HTR1ADRD2HTR2APDE3BPDE3A | |
| SCHEMBL9209880 | 0.70 | HTR1A (0.41) | HTR1ADRD2HTR2APDE3BPDE3A | |
| SCHEMBL7318244 | 0.70 | ALDH1A1 (0.56) | HTR1ADRD2HTR2APDE3BPDE3A | |
| SCHEMBL14506177 | 0.69 | ALDH1A1 (0.55) | HTR1ADRD2HTR2APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4804658-A | PLATELET-ACTIVATING FACTOR ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-02-14 | — | — | US | claimed |
| EP-0260613-A2 | Imidazopyridine derivatives, their preparation and their use as PAF-antagonists | G.D. Searle & Co. (US) | 1988-03-23 | — | — | EP | claimed |
| US-4962106-A | Treating platelet activating factor mediated disorders | G. D. SEARLE & CO. (US) | 1990-10-09 | — | — | US | disclosed |
| US-4804658-A | PLATELET-ACTIVATING FACTOR ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0260613-A2 | Imidazopyridine derivatives, their preparation and their use as PAF-antagonists | G.D. Searle & Co. (US) | 1988-03-23 | — | — | EP | disclosed |