SCHEMBL10469596

SCHEMBL10469596

O=C1CC2(CCC(O)C2)CC(=O)N1CCCCN1CCN(C2=NS(=O)(=O)c3ccccc32)CC1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
HTR1A P08908 4/20 0.46
SLC22A2 O15244 1/20 0.43
ABCB11 O95342 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
DRD2 P14416 1/20 0.43
ADRA2C P18825 1/20 0.43
CNR1 P21554 1/20 0.43
ADRA1D P25100 1/20 0.43
HTR2A P28223 1/20 0.43
HTR2C P28335 1/20 0.43
HTR7 P34969 1/20 0.43
ADRA1A P35348 1/20 0.43
HRH1 P35367 1/20 0.43
ADRA1B P35368 1/20 0.43
DRD3 P35462 1/20 0.43
HTR2B P41595 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10471021 0.75 HTR1A (0.61) HTR1ADRD2HTR2AHTR7ADRA1A
SCHEMBL10469564 0.74 HTR1A (0.45) HTR1A
SCHEMBL27596185 0.72 ALDH1A1 (0.68) ALDH1A1TSHRSMN1; SMN2
SCHEMBL7979120 0.70 ALDH1A1 (0.50) ALDH1A1TSHRSMN1; SMN2
SCHEMBL10469591 0.68 HSD11B1 (0.36) ALDH1A1HTR1ASLC22A2ABCB11CYP1A2
Hydrochloric Acid SCHEMBL9593885 0.66 ALDH1A1 (0.49) ALDH1A1TSHRSMN1; SMN2
SCHEMBL10441355 0.65 HTR1A (0.75) ALDH1A1HTR1ASLC22A2ABCB11CYP1A2
Hydrochloric Acid SCHEMBL11881897 0.64 ALDH1A1 (0.76) ALDH1A1HTR1ASLC22A2ABCB11CYP1A2
SCHEMBL16804116 0.64 ALDH1A1 (0.49) ALDH1A1HTR1AABCB11DRD2ADRA2C
SCHEMBL20952436 0.63 TSHR (0.72) ALDH1A1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4956368-A Antipsychotic agents BRISTOL-MYERS COMPANY (US) 1990-09-11 US claimed