Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | TTPA | P49638 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | PREP | P48147 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599903 | 0.89 | MEN1 (0.38) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL9201685 | 0.88 | MEN1 (0.37) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL9851204 | 0.88 | MEN1 (0.37) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL9201691 | 0.88 | MEN1 (0.37) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL9207314 | 0.86 | TTPA (0.39) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL9207302 | 0.86 | TTPA (0.39) | MEN1KMT2APDE4APDE3ATTPA | |
| Raxofelast SCHEMBL633620 | 0.83 | THRA (0.40) | MEN1KMT2APDE4APDE3ATTPA | |
| Raxofelast SCHEMBL633619 | 0.83 | THRA (0.40) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL9207912 | 0.82 | KDM4E (0.30) | — | |
| SCHEMBL9786760 | 0.82 | MEN1 (0.36) | MEN1KMT2APDE4APDE3ATTPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4978761-A | Enzyme inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-12-18 | — | — | US | disclosed |
| EP-0345593-A1 | 2-substituted coumaran derivatives | Takeda Chemical Industries, Ltd. (JP) | 1989-12-13 | — | — | EP | disclosed |