Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474115 | 1.00 | LMNA (0.31) | LMNAMAPTPTGER2PTGER4PTGER3 | |
| SCHEMBL10473298 | 0.86 | PDE4A (0.35) | MAPT | |
| SCHEMBL10473627 | 0.86 | PDE4A (0.35) | MAPT | |
| SCHEMBL10474832 | 0.80 | MEN1 (0.30) | — | |
| SCHEMBL10474833 | 0.80 | MEN1 (0.30) | — | |
| SCHEMBL11178051 | 0.78 | — | — | |
| SCHEMBL10472629 | 0.78 | ESR1 (0.34) | — | |
| SCHEMBL10472628 | 0.78 | ESR1 (0.34) | — | |
| SCHEMBL10472041 | 0.76 | ESR1 (0.34) | — | |
| SCHEMBL10976470 | 0.73 | HTR1A (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920221-A | CENTRAL NERVOUS SYSTEM ACTIVE AGENTS | PFIZER INC. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4642373-A | Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents | PFIZER INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4473704-A | ANALGESICS, ANTIEMETICS | PFIZER INC. (US) | 1984-09-25 | — | — | US | disclosed |