Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.30 |
| ▸ | DRD1 | P21728 | 6/20 | 0.30 |
| ▸ | DRD4 | P21917 | 6/20 | 0.30 |
| ▸ | DRD5 | P21918 | 6/20 | 0.30 |
| ▸ | DRD3 | P35462 | 6/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 5/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10973060 | 0.87 | PDE4A (0.35) | — | |
| SCHEMBL11178470 | 0.81 | ESR2 (0.30) | ESR2 | |
| SCHEMBL11385079 | 0.76 | PTPN1 (0.34) | — | |
| SCHEMBL11178051 | 0.75 | — | — | |
| SCHEMBL11187956 | 0.74 | PDE4A (0.37) | — | |
| SCHEMBL11225268 | 0.74 | S1PR1 (0.39) | — | |
| SCHEMBL10474116 | 0.73 | LMNA (0.31) | — | |
| SCHEMBL10474115 | 0.73 | LMNA (0.31) | — | |
| SCHEMBL10977283 | 0.72 | CNR2 (0.35) | — | |
| SCHEMBL10471851 | 0.68 | ESR1 (0.32) | HTR1ADRD1DRD4DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045171-B1 | 9-AMINO-1-HYDROXYOCTAHYDROBENZO(C)QUINOLINES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1985-02-13 | — | — | EP | disclosed |
| US-4351833-A | 9-Amino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof as analgesics and anti-emetics | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| EP-0045171-A2 | 9-Amino-1-hydroxyoctahydrobenzo(c)quinolines and derivatives thereof | PFIZER INC. (US) | 1982-02-03 | — | — | EP | disclosed |
| US-4309545-A | ANALGESICS, TRANQUILIZERS, ANTIEMETICS, DIURETICS, ANTICONVULSANTS, ANTIDIARRHEAL, ANTITUSSIVES AND IN THE TREATMENT OF GLAUCOMA | PFIZER INC. (US) | 1982-01-05 | — | — | US | disclosed |