Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 13/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | MAOB | P27338 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | RECQL | P46063 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474665 | 1.00 | PTGS2 (0.63) | PTGS2MAPTALDH1A1MAOBRAB9A | |
| SCHEMBL29055983 | 0.87 | PTGS2 (0.60) | PTGS2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL3940157 | 0.83 | MAPT (0.56) | PTGS2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL13592347 | 0.83 | MAPT (0.56) | PTGS2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL13657919 | 0.81 | ALDH1A1 (0.59) | PTGS2MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8312599 | 0.80 | L3MBTL1 (0.58) | PTGS2MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL30863768 | 0.79 | MAPT (0.86) | PTGS2MAPTALDH1A1MAOBRAB9A | |
| SCHEMBL23251385 | 0.79 | MAPT (0.81) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7135274 | 0.78 | MAOB (0.61) | MAPTALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL6262087 | 0.78 | MAOB (0.62) | MAPTALDH1A1MAOBRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904658-A | Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones | AMERICAN CYANAMID COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4888345-A | HYPOTENSIVE AND ANXIOLYTIC AGENTS; CHEMICAL INTERMEDIATES | AMERICAN CYANAMID COMPANY (US) | 1989-12-19 | — | — | US | disclosed |