Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19568160 | 0.77 | CRHR1 (0.51) | CYP1A2HPGDCYP2C19P2RX7KDM4E | |
| SCHEMBL12268127 | 0.76 | POLB (0.52) | POLBCYP1A2HPGDCYP2C19KDM4E | |
| SCHEMBL9901661 | 0.76 | MAPK1 (0.45) | POLBCYP1A2HPGDCYP2C19P2RX7 | |
| Hydrochloric Acid SCHEMBL31393258 | 0.76 | POLB (0.52) | POLBCYP1A2HPGDCYP2C19KDM4E | |
| SCHEMBL10475404 | 0.75 | GAA (0.51) | POLBHPGDP2RX7ALDH1A1MAPT | |
| SCHEMBL641433 | 0.74 | POLB (0.54) | POLBCYP1A2HPGDCYP2C19KDM4E | |
| SCHEMBL11875730 | 0.73 | ALDH1A1 (0.61) | POLBCYP1A2P2RX7KDM4EALDH1A1 | |
| SCHEMBL9462103 | 0.72 | CRHR1 (0.54) | POLBCYP1A2HPGDCYP2C19P2RX7 | |
| SCHEMBL20984777 | 0.72 | KDM4E (0.59) | POLBCYP1A2HPGDCYP2C19P2RX7 | |
| SCHEMBL3950057 | 0.72 | POLB (0.52) | POLBCYP1A2HPGDCYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4943583-A | PESTICIDES | HOFFMANN-LA ROCHE INC. (US) | 1990-07-24 | — | — | US | disclosed |
| EP-0270061-A2 | Five-membered heterocycles with three heteroatoms, their preparation and their use as pesticides | CIBA-GEIGY AG (CH) | 1988-06-08 | — | — | EP | disclosed |