Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 1/20 | 0.66 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 5/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31546 | 0.80 | PRKAA2 (1.00) | PRKAA2GRM2ADORA2ASMN1; SMN2GCGR | |
| SCHEMBL30060873 | 0.80 | PRKAA2 (1.00) | PRKAA2GRM2ADORA2ASMN1; SMN2GCGR | |
| SCHEMBL8327767 | 0.80 | GCGR (0.64) | PRKAA2GCGR | |
| SCHEMBL10474175 | 0.74 | RXRA (0.46) | PRKAA2GRM2ADORA2ASMN1; SMN2TNKS | |
| SCHEMBL5860123 | 0.72 | KDM4E (0.43) | SMN1; SMN2DHODH | |
| SCHEMBL10474547 | 0.72 | SMN1; SMN2 (0.63) | SMN1; SMN2SCN9A | |
| SCHEMBL3709827 | 0.71 | PRKAA2 (0.77) | PRKAA2ADORA2ASMN1; SMN2TNKSTNKS2 | |
| SCHEMBL5501886 | 0.71 | SMN1; SMN2 (0.70) | PRKAA2SMN1; SMN2GCGR | |
| SCHEMBL28949590 | 0.71 | RORC (0.49) | — | |
| SCHEMBL8877962 | 0.70 | HMGCR (0.53) | PRKAA2ADORA2ASMN1; SMN2GCGRDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4923861-A | 6-(2-(2-(Substituted amino)-3-quinolinyl) ethenyl and ethyl) tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1990-05-08 | — | — | US | disclosed |