Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474212 | 0.80 | KDM4E (0.46) | RXRATNKSTNKS2PARP2PRKAA2 | |
| SCHEMBL8321756 | 0.80 | GCGR (0.46) | RXRATNKSTNKS2PARP2PRKAA2 | |
| SCHEMBL29419163 | 0.79 | RXRA (0.67) | RXRATNKSTNKS2PARP2PRKAA2 | |
| SCHEMBL244423 | 0.79 | RXRA (0.67) | RXRATNKSTNKS2PARP2PRKAA2 | |
| SCHEMBL28261499 | 0.78 | RXRA (0.44) | RXRATNKSTNKS2PARP2PRKAA2 | |
| SCHEMBL27560748 | 0.77 | RXRA (0.62) | RXRATNKSTNKS2PARP2PRKAA2 | |
| SCHEMBL11359732 | 0.77 | ADORA2A (0.44) | TNKSTNKS2PARP2GRM2ADORA2A | |
| SCHEMBL4860650 | 0.75 | MAOA (0.55) | KDM4ERXFP1PDE4DERN1NPSR1 | |
| SCHEMBL10475261 | 0.74 | PRKAA2 (0.66) | TNKSTNKS2PARP2PRKAA2GRM2 | |
| SCHEMBL23780919 | 0.72 | ERN1 (0.45) | KDM4ERXFP1PDE4DERN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4923861-A | 6-(2-(2-(Substituted amino)-3-quinolinyl) ethenyl and ethyl) tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1990-05-08 | — | — | US | disclosed |