Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.68 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | KIF11 | P52732 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.58 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.58 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL104275 | 0.90 | NPC1 (0.68) | PTPN1LMNAKDM4ETRPV1POLB | |
| SCHEMBL2563194 | 0.90 | NPC1 (0.68) | PTPN1LMNAKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL23844169 | 0.88 | LMNA (0.76) | LMNAKDM4ETRPV1POLBSMN1; SMN2 | |
| SCHEMBL19501816 | 0.88 | SIRT1 (0.70) | PTPN1LMNAKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL26915306 | 0.85 | LMNA (0.68) | LMNAKDM4ETRPV1POLBSMN1; SMN2 | |
| SCHEMBL8461727 | 0.85 | LMNA (0.68) | LMNAKDM4ETRPV1POLBSMN1; SMN2 | |
| SCHEMBL14082561 | 0.85 | NPC1 (0.74) | DEGS1LMNAKDM4ETRPV1POLB | |
| SCHEMBL22699716 | 0.84 | TRPV1 (0.63) | PTPN1DEGS1TRPV1SMN1; SMN2MAPT | |
| SCHEMBL27837892 | 0.83 | LMNA (0.65) | PTPN1LMNAKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL10136221 | 0.83 | PTPN1 (0.96) | PTPN1DEGS1KDM4ETRPV1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | NR0B1, GRK7, NR5A2 | PTPN1 1597/4885DEGS1 4690/4885LMNA 3669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.