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Sugi Predict / Targets / GRK7

GRK7

Rhodopsin kinase GRK7 · Q8WTQ7 · GRK7 on Sugi Atlas →

4,564 patent compounds predicted against GRK7, 3,646 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL187199 SCHEMBL187199 0.44 3/20
Tofacitinib Tofacitinib (SCHEMBL322753) 1.00 2/20
Tofacitinib Tofacitinib (SCHEMBL1120705) 1.00 2/20
Tofacitinib Tofacitinib (SCHEMBL1374185) 1.00 2/20
SCHEMBL2323500 SCHEMBL2323500 0.85 2/20
SCHEMBL3065509 SCHEMBL3065509 0.85 2/20
SCHEMBL2320931 SCHEMBL2320931 0.80 2/20
SCHEMBL3683647 SCHEMBL3683647 0.80 2/20
SCHEMBL4061567 SCHEMBL4061567 0.78 2/20
SCHEMBL1846276 SCHEMBL1846276 0.78 2/20
SCHEMBL4069759 SCHEMBL4069759 0.78 2/20
SCHEMBL2319641 SCHEMBL2319641 0.77 2/20
SCHEMBL3678056 SCHEMBL3678056 0.77 2/20
SCHEMBL4062773 SCHEMBL4062773 0.77 2/20
SCHEMBL4070029 SCHEMBL4070029 0.77 2/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL4066429) 0.76 2/20
SCHEMBL4068174 SCHEMBL4068174 0.76 2/20
SCHEMBL2148397 SCHEMBL2148397 0.75 2/20
SCHEMBL353500 SCHEMBL353500 0.75 2/20
SCHEMBL2319231 SCHEMBL2319231 0.75 2/20

Clinical trials — most relevant to GRK7 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression. PHASE4UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With XLRP PHASE2/PHASE3ACTIVE_NOT_RECRUITING
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room PHASE2/PHASE3COMPLETED
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients PHASE3COMPLETED
A Study Comparing Two Doses of AGTC-501 in Male Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (SKYLINE) PHASE2ACTIVE_NOT_RECRUITING
Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations PHASE1/PHASE2UNKNOWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Dose Ranging Study of Carbidopa-levodopa PHASE2COMPLETED
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration PHASE2WITHDRAWN
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
A Pharmacodynamic Study of Leuprorelin Gelatin-Free Formulation in Female Subjects With Uterine Fibroids. PHASE2COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses PHASE1UNKNOWN
Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine EARLY_PHASE1COMPLETED
Genetic Predictors of Lithium Response in Bipolar Disorder nanCOMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease nanCOMPLETED
Investigating the Metabolic and Lipidomic Profiles That Are Associated With Varying Grades of Diabetic Maculopathy and Retinopathy in South Wales nanRECRUITING
Acamprosate: Genes Associated With Response nanCOMPLETED
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome nanACTIVE_NOT_RECRUITING
A Phase I Trial of AVN944, an IMPDH Inhibitor, in Adults With Advanced Stage Solid Tumors nanWITHDRAWN
Identification of Cellular Biomarkers of Rare Eye Diseases in Adults nanNOT_YET_RECRUITING
Steroid Treatment of Idiopathic Nephrotic Syndrome nanCOMPLETED
Safety and Efficacy of Combination Acthar Gel and Tacrolimus in the Treatment of Steroid Resistant Nephrotic Syndrome nanSUSPENDED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
TELEMEDICINE,Maintenance of a Respiratory Rehabilitation Program in Patients With Chronic Obstructive Pulmonary Disease. nanCOMPLETED
Effect of Symbicort on GR Localisation in Asthma nanCOMPLETED
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GRK7 binder may also engage these)

ProteinNameSimilarity
Q8WP15 — 1.000 Q8WP15 →
B6CZ17 — 0.998 B6CZ17 →
Q8WMV0 — 0.994 Q8WMV0 →
Q9Z2G7 — 0.993 Q9Z2G7 →
Q1XHL7 — 0.989 Q1XHL7 →
B6CZ18 — 0.988 B6CZ18 →
P28327 — 0.987 P28327 →
Q622Z7 — 0.987 Q622Z7 →
P13678 — 0.986 P13678 →
Q49HM9 — 0.985 Q49HM9 →
P63318 — 0.985 P63318 →
P63319 — 0.985 P63319 →
GRK1 Rhodopsin kinase GRK1 0.985 landscape →
Q63651 — 0.985 Q63651 →
Q9WVC6 — 0.984 Q9WVC6 →
Q4R4U2 — 0.984 Q4R4U2 →
Q5PU49 — 0.983 Q5PU49 →
Q9WVL4 — 0.983 Q9WVL4 →
D3ZHP7 — 0.983 D3ZHP7 →
Q16974 — 0.982 Q16974 →
Q09537 — 0.982 Q09537 →
P04409 — 0.981 P04409 →
PRKCA Protein kinase C alpha type 0.980 landscape →
Q9XTG7 — 0.980 Q9XTG7 →
P31938 — 0.980 P31938 →
Q6PFQ0 — 0.979 Q6PFQ0 →
Q7TSE6 — 0.979 Q7TSE6 →
P05128 — 0.978 P05128 →
P23298 — 0.978 P23298 →
PRKCB Protein kinase C beta type 0.978 landscape →