Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8681504 | 0.83 | ALDH1A1 (0.53) | ALDH1A1ALOX15HTTSLC40A1EGLN1 | |
| SCHEMBL10477489 | 0.80 | ALDH1A1 (0.51) | ALDH1A1ALOX15HTTSLC40A1EGLN1 | |
| SCHEMBL3203066 | 0.76 | EGLN1 (0.47) | ALDH1A1ALOX15HTTSLC40A1EGLN1 | |
| SCHEMBL24960020 | 0.76 | ALDH1A1 (0.60) | ALDH1A1ALOX15HTTKDM4EL3MBTL1 | |
| SCHEMBL4348296 | 0.74 | ALDH1A1 (0.62) | ALDH1A1ALOX15DYRK1ADYRK1BKDM4E | |
| SCHEMBL10477382 | 0.73 | ALDH1A1 (0.47) | ALDH1A1ALOX15HTTDYRK1ADYRK1B | |
| SCHEMBL10477383 | 0.72 | ALDH1A1 (0.41) | ALDH1A1ALOX15HTTSLC40A1EGLN1 | |
| SCHEMBL19224594 | 0.71 | ALDH1A1 (0.59) | ALDH1A1ALOX15DYRK1ADYRK1BKDM4E | |
| SCHEMBL28675526 | 0.71 | HTT (0.52) | ALDH1A1ALOX15HTTSLC40A1EGLN1 | |
| SCHEMBL10477389 | 0.70 | ALOX15 (0.48) | ALDH1A1ALOX15HTTSLC40A1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327052-A2 | Use of quinoline derivatives for making a medicament effective in the prevention and treatment of ulcers | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-08-09 | — | — | EP | disclosed |
| US-4831040-A | (IMIDAZOLO-, THIAZOLO-, OXAZOLO-)(4,5-H)-QUINOLINE | RORER PHARMACEUTICAL CORPORATION (US) | 1989-05-16 | — | — | US | disclosed |
| EP-0090360-B1 | NEW QUINOLINE AND RELATED COMPOUNDS USEFUL AS ANTI-ALLERGY AGENTS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1988-05-18 | — | — | EP | disclosed |
| US-4698346-A | Thiazolo[5,4-h]quinoline compounds useful as anti-allergy agents | USV PHARMACEUTICAL CORPORATION (US) | 1987-10-06 | — | — | US | disclosed |
| US-4656281-A | Imidazo quinoline compounds useful as anti-allergy agents | USV PHARMACEUTICAL CORP. (US) | 1987-04-07 | — | — | US | disclosed |
| US-4563463-A | ASTHMA | USV PHARMACEUTICAL CORP. (US) | 1986-01-07 | — | — | US | disclosed |
| US-4522947-A | Certain 1,3-oxazolo[4,5H]quinolines useful as anti-allergy agents | USV PHARMACEUTICAL CORPORATION (US) | 1985-06-11 | — | — | US | disclosed |
| EP-0090360-A2 | New quinoline and related compounds useful as anti-allergy agents | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-10-05 | — | — | EP | disclosed |