Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SLC40A1 | Q9NP59 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477449 | 0.80 | ALDH1A1 (0.50) | ALDH1A1SLC40A1MAPTKDM4EEGLN1 | |
| SCHEMBL28675526 | 0.75 | HTT (0.52) | ALDH1A1SLC40A1MAPTKDM4EEGLN1 | |
| SCHEMBL4348292 | 0.74 | ALDH1A1 (0.60) | ALDH1A1MAPTKDM4EHTTSMN1; SMN2 | |
| SCHEMBL1040735 | 0.74 | DYRK1A (0.63) | ALDH1A1MAPTKDM4EHTTSMN1; SMN2 | |
| SCHEMBL29749248 | 0.72 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4EHTTSMN1; SMN2 | |
| SCHEMBL3398107 | 0.72 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4EHTTSMN1; SMN2 | |
| SCHEMBL28368126 | 0.72 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4EHTTSMN1; SMN2 | |
| SCHEMBL12020192 | 0.72 | KDM4E (0.55) | ALDH1A1SLC40A1MAPTKDM4EEGLN1 | |
| SCHEMBL4859920 | 0.71 | LIMK1 (0.49) | ALDH1A1MAPTKDM4EHTTSMN1; SMN2 | |
| SCHEMBL27994689 | 0.71 | PSMD14 (0.64) | ALDH1A1SLC40A1MAPTKDM4EEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327052-A2 | Use of quinoline derivatives for making a medicament effective in the prevention and treatment of ulcers | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-08-09 | — | — | EP | disclosed |
| US-4831040-A | (IMIDAZOLO-, THIAZOLO-, OXAZOLO-)(4,5-H)-QUINOLINE | RORER PHARMACEUTICAL CORPORATION (US) | 1989-05-16 | — | — | US | disclosed |
| US-4698346-A | Thiazolo[5,4-h]quinoline compounds useful as anti-allergy agents | USV PHARMACEUTICAL CORPORATION (US) | 1987-10-06 | — | — | US | disclosed |
| US-4563463-A | ASTHMA | USV PHARMACEUTICAL CORP. (US) | 1986-01-07 | — | — | US | disclosed |