Citric Acid

Citric Acid

SCHEMBL10477646

O=C([O-])CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)O)C(=O)O.[Na+].[Na+]

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.36
ALDH1A1 P00352 2/20 0.71
CA4 P22748 2/20 0.58
HMGCR P04035 1/20 0.39
CHRM1 P11229 1/20 0.39
TBXA2R P21731 1/20 0.39
ADRA1A P35348 1/20 0.39
TSHR P16473 2/20 0.38
KDM4E B2RXH2 2/20 0.38
LMNA P02545 2/20 0.38
MAPT P10636 1/20 0.38
ALOX15 P16050 1/20 0.38
CYP2D6 P10635 2/20 0.37
CYP2C19 P33261 1/20 0.37
HIF1A Q16665 1/20 0.37
SLC13A5 Q86YT5 4/20 0.37
ACLY P53396 3/20 0.37
CYP1A2 P05177 1/20 0.36
KMT2A Q03164 1/20 0.36
CPT2 P23786 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL73101 1.00 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL2235362 1.00 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL9125740 1.00 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL150577 1.00 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL3388434 0.98 ALDH1A1 (0.68) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL2544645 0.98 ALDH1A1 (0.68) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL8806048 0.98 ALDH1A1 (0.68) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL11131940 0.98 ALDH1A1 (0.68) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL11882611 0.98 ALDH1A1 (0.68) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL2345211 0.98 ALDH1A1 (0.68) ALDH1A1CA4HMGCRCHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021061066-A1 EFFERVESCENT FORMULATIONS OF SAPROPTERIN DIHYDROCHLORIDE SANOVEL ILAC SANAYI VE TICARET ANONIM SIRKETI (TR) 2021-04-01 WO claimed
EP-2870961-B1 Effervescent formulations of pramipexole SANOVEL ILAC SANAYI VE TICARET AS (TR) 2018-07-18 EP claimed
EP-2870961-A1 Effervescent formulations of pramipexole Sanovel Ilac Sanayi ve Ticaret A.S. (TR) 2015-05-13 EP claimed
EP-4376973-A1 MOLECULAR IMPRINTED POLYMER AND USE THEREOF IN QUANTIFYING A PESTICIDE IN A SAMPLE Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (FR) 2024-06-05 EP disclosed
WO-2023006895-A1 MOLECULAR IMPRINTED POLYMER AND USE THEREOF IN QUANTIFYING A PESTICIDE IN A SAMPLE ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS (FR) 2023-02-02 WO disclosed
WO-2021061066-A1 EFFERVESCENT FORMULATIONS OF SAPROPTERIN DIHYDROCHLORIDE SANOVEL ILAC SANAYI VE TICARET ANONIM SIRKETI (TR) 2021-04-01 WO disclosed
EP-2870961-B1 Effervescent formulations of pramipexole SANOVEL ILAC SANAYI VE TICARET AS (TR) 2018-07-18 EP disclosed
EP-3212234-A1 PHARMACEUTICAL COMBINATIONS OF SITAGLIPTIN AND PPAR AGONISTS Sanovel Ilac Sanayi ve Ticaret A.S. (TR) 2017-09-06 EP disclosed
EP-3212185-A1 PHARMACEUTICAL COMBINATIONS OF VILDAGLIPTIN AND PPAR AGONISTS Sanovel Ilac Sanayi ve Ticaret A.S. (TR) 2017-09-06 EP disclosed
WO-2016066668-A1 PHARMACEUTICAL COMBINATIONS OF VILDAGLIPTIN AND PPAR AGONISTS SANOVEL ILAC SANAYI VE TICARET A.S. (TR) 2016-05-06 WO disclosed
WO-2016066666-A1 PHARMACEUTICAL COMBINATIONS OF SITAGLIPTIN AND PPAR AGONISTS SANOVEL ILAC SANAYI VE TICARET A.S. (TR) 2016-05-06 WO disclosed
EP-2870961-A1 Effervescent formulations of pramipexole Sanovel Ilac Sanayi ve Ticaret A.S. (TR) 2015-05-13 EP disclosed
US-4824664-A ANTIHISTAMINES LABORATOIRES SMITH KLINE & FRENCH (FR) 1989-04-25 US disclosed