Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | CA4 | P22748 | 2/20 | 0.58 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.37 |
| ▸ | ACLY | P53396 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL2235362 | 1.00 | ALDH1A1 (0.71) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL9125740 | 1.00 | ALDH1A1 (0.71) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL150577 | 1.00 | ALDH1A1 (0.71) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL10477646 | 1.00 | ALDH1A1 (0.71) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL3388434 | 0.98 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL2544645 | 0.98 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL8806048 | 0.98 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL11131940 | 0.98 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL11882611 | 0.98 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL2345211 | 0.98 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9466 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116553684-B | Device and method for electrochemical oxidation total denitrification of ammonia nitrogen wastewater | EAST CHINA JIAOTONG UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122094666-A | Pharmaceutical composition comprising simethicone and alverine citrate, pharmaceutical composition comprising simethicone, pharmaceutical composition comprising alverine citrate and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122017257-A | Detection method and detection kit for oxidized low-density lipoprotein | 济南玖方生物科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-20260115225-A1 | Effervescent Laxative Composition | L PERRIGO COMPANY (US) | 2026-04-30 | — | — | US | claimed |
| EP-4727587-A1 | INJECTABLE COMPOSITE DEPOT | DelSiTech Oy (FI) | 2026-04-22 | — | — | EP | claimed |
| EP-4720314-A1 | AAV PURIFICATION METHOD | Juno Therapeutics, Inc. (US) | 2026-04-08 | — | — | EP | claimed |
| US-12590187-B2 | Polymer composite capable of being quickly dissolved or dispersed in aqueous solvent and preparation method and application thereof | FUDAN UNIVERSITY (CN) | 2026-03-31 | — | — | US | claimed |
| US-12576265-B2 | Conductive gel compositions and methods of production and use thereof | NOVOCURE GMBH (CH) | 2026-03-17 | — | — | US | claimed |
| US-12569864-B2 | Liquid dispensing product having a spray dispenser | THE PROCTER & GAMBLE COMPANY (US) | 2026-03-10 | — | — | US | claimed |
| US-20260060973-A1 | Ophthalmic Composition for Treating Non-Infectious Inflammatory Diseases | VIVAVISION BIOTECH LTD (CN) | 2026-03-05 | — | — | US | claimed |
| EP-0154523-A2 | A pharmaceutical formulation containing azapropazone | Rainsford, Kim Drummond (GB) | 1985-09-11 | — | — | EP | claimed |
| EP-0143545-A2 | Masterbatch composition containing a resin and a foaming agent | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1985-06-05 | — | — | EP | claimed |
| EP-0059495-B1 | A POLYVINYLIDENE FLUORIDE COMPOSITION WITH A BLOWING AGENT | SOLVAY & Cie (Société Anonyme) (BE) | 1984-05-16 | — | — | EP | claimed |
| US-4444800-A | SOLVATION AGENT | L.D. SCHREIBER CHEESE CO., INC. (US) | 1984-04-24 | — | — | US | claimed |
| EP-0011489-B1 | AN ANALGESIC EFFERVESCENT POWDER AND PROCESS FOR ITS PREPARATION | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | claimed |
| US-4346709-A | Drug delivery devices comprising erodible polymer and erosion rate modifier | ALZA CORPORATION (US) | 1982-08-31 | — | — | US | claimed |
| US-4309408-A | ACETAMINOPHEN AND METOCLOPRAMIDE; ANALGESIC FOR MIGRAINE HEADACHES | BEECHAM GROUP LIMITED (GB) | 1982-01-05 | — | — | US | claimed |
| US-4217144-A | FIREPROOFING | LAFARGE FONDU INTERNATIONAL (FR) | 1980-08-12 | — | — | US | claimed |
| EP-0011489-A1 | An analgesic effervescent powder and process for its preparation | BEECHAM GROUP PLC (GB) | 1980-05-28 | — | — | EP | claimed |
| US-4200586-A | Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds | PHILLIPS PETROLEUM COMPANY (US) | 1980-04-29 | — | — | US | claimed |