Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 6/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10720602 | 0.91 | CASP3 (0.60) | CASP1CASP3CTSB | |
| SCHEMBL7806358 | 0.89 | CASP3 (0.62) | CASP1CASP3CTSBALDH1A1CYP1A2 | |
| SCHEMBL10722827 | 0.86 | CTSB (0.50) | CTSBCAPN1CTRB1 | |
| SCHEMBL7277023 | 0.84 | CASP1 (0.63) | CASP1CASP3TGM2TACR1HRH4 | |
| SCHEMBL10976664 | 0.84 | CASP1 (0.63) | CASP1CASP3TGM2TACR1HRH4 | |
| SCHEMBL29523231 | 0.84 | CASP1 (0.63) | CASP1CASP3TGM2TACR1HRH4 | |
| SCHEMBL7444765 | 0.84 | CASP1 (0.63) | CASP1CASP3TGM2TACR1HRH4 | |
| SCHEMBL29523440 | 0.84 | CASP1 (0.63) | CASP1CASP3TGM2TACR1HRH4 | |
| SCHEMBL10720567 | 0.84 | CTSB (0.49) | CTSBCTRB1 | |
| SCHEMBL10720707 | 0.83 | HDAC1 (0.49) | CTSBCAPN1CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247665-A1 | PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS | EMORY UNIVERSITY (US) | 2020-12-10 | — | — | WO | disclosed |
| US-4857650-A | Novel renin inhibitory amino acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| US-4853463-A | Amino acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-01 | — | — | US | disclosed |
| US-4698329-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0206807-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-12-30 | — | — | EP | disclosed |
| EP-0200406-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-11-05 | — | — | EP | disclosed |
| EP-0190891-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-08-13 | — | — | EP | disclosed |
| EP-0152255-A2 | New renin-inhibitory peptides and their use | SANKYO COMPANY LIMITED (JP) | 1985-08-21 | — | — | EP | disclosed |