Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10478268 | 0.99 | OPRM1 (0.50) | OPRM1DRD4SIGMAR1DRD2KCNH2 | |
| SCHEMBL10478166 | 0.83 | DRD4 (0.49) | OPRM1DRD4SIGMAR1KCNH2CYP2D6 | |
| SCHEMBL10478243 | 0.81 | OPRM1 (0.54) | OPRM1SIGMAR1DRD2KCNH2SLC6A4 | |
| Hydrochloric Acid SCHEMBL10478080 | 0.80 | OPRM1 (0.46) | OPRM1DRD4SIGMAR1DRD2KCNH2 | |
| Hydrochloric Acid SCHEMBL10477989 | 0.78 | OPRM1 (0.43) | OPRM1DRD4SIGMAR1DRD2KCNH2 | |
| Oxalic Acid SCHEMBL10478016 | 0.77 | ACKR3 (0.45) | DRD2 | |
| Oxalic Acid SCHEMBL10478225 | 0.77 | KCNA3 (0.41) | OPRM1ADRA1AOPRD1OPRK1 | |
| SCHEMBL11738164 | 0.76 | OPRM1 (0.77) | OPRM1DRD4SIGMAR1DRD2KCNH2 | |
| Hydrochloric Acid SCHEMBL11747049 | 0.74 | OPRM1 (0.74) | OPRM1DRD4SIGMAR1DRD2KCNH2 | |
| SCHEMBL17001809 | 0.73 | CHRM2 (0.44) | CHRM2CHRM1SLC6A4OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845095-A | ANALGESICS, NEUROLEPTICS | A/S FERROSAN (DK) | 1989-07-04 | — | — | US | disclosed |
| EP-0285032-A1 | 4-Phenylpiperidine compounds and their preparation and use | A/S FERROSAN (DK) | 1988-10-05 | — | — | EP | disclosed |