SCHEMBL10482148

SCHEMBL10482148

Cc1nc(Cl)c(S(C)(=O)=O)c(Cl)n1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
HPGD P15428 2/20 0.34
GAA P10253 5/20 0.33
KDM4E B2RXH2 3/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 3/20 0.33
MEN1 O00255 1/20 0.33
GLA P06280 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
LMNA P02545 1/20 0.31
GLP1R P43220 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9619744 0.82 ALDH1A1 (0.35) HTTL3MBTL1HPGDGAAKDM4E
SCHEMBL10583192 0.80 SMN1; SMN2 (0.40) HTTL3MBTL1HPGDALDH1A1MAPT
SCHEMBL10957760 0.80 GLP1R (0.38) HTTL3MBTL1HPGDGAAKDM4E
SCHEMBL10813621 0.73 CASP1 (0.31) HTTL3MBTL1HPGDLMNA
SCHEMBL11151048 0.73 KDM4E (0.36) HTTL3MBTL1HPGDGAAKDM4E
SCHEMBL68355 0.72 CASP1 (0.33) HTTGAAKDM4EALDH1A1MAPT
SCHEMBL27519287 0.70 TP53 (0.33) HTTL3MBTL1HPGDGAAKDM4E
SCHEMBL10958096 0.70 GAA (0.33) GAAKDM4EALDH1A1MAPTLMNA
SCHEMBL10955974 0.70 GLP1R (0.39) GAAKDM4EALDH1A1MAPTLMNA
SCHEMBL9619816 0.69 CASP1 (0.32) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4801693-A DYEING WOOL, CELLULOSE, OR COTTON BASF AKTIENGESELLSCHAFT (DE) 1989-01-31 US disclosed
EP-0132223-B1 REACTIVE DYES, THEIR PREPARATION AND THEIR USE CIBA-GEIGY AG (CH) 1987-09-30 EP disclosed
US-4677199-A Reactive dyes containing substituted 4-fluoropyridaz-6-one radicals BASF AKTIENGESELLSCHAFT (DE) 1987-06-30 US disclosed
EP-0119441-B1 REACTIVE DYES WITH SUBSTITUTED 4-FLUOROPYRIDAZ-6-ONE GROUPS BASF Aktiengesellschaft (DE) 1987-02-25 EP disclosed
US-4631065-A Reactive dyes, process for their preparation and use thereof CIBA-GEIGY CORPORATION (US) 1986-12-23 US disclosed
EP-0167785-A1 Reactive dyes BASF Aktiengesellschaft (DE) 1986-01-15 EP disclosed
EP-0055214-B1 2-ALKYL-5-ALKYLSULFONYL-4,6-DIHALOGEN PYRIMIDINES AND PROCESS FOR THEIR PREPARATION CIBA-GEIGY AG (CH) 1985-05-22 EP disclosed
EP-0132223-A1 Reactive dyes, their preparation and their use CIBA-GEIGY AG (CH) 1985-01-23 EP disclosed
EP-0119441-A2 Reactive dyes with substituted 4-fluoropyridaz-6-one groups BASF Aktiengesellschaft (DE) 1984-09-26 EP disclosed
US-4413124-A 2-Alkyl-5-alkylsulfonyl-4,6-dihalopyrimidines and the production thereof CIBA-GEIGY CORPORATION (US) 1983-11-01 US disclosed
US-4412074-A 2-Alkyl-5-alkyl sulfony 1-4,6-dihalopyrimidines and the production thereof CIBA-GEIGY CORPORATION (US) 1983-10-25 US disclosed
EP-0055214-A1 2-Alkyl-5-alkylsulfonyl-4,6-dihalogen pyrimidines and process for their preparation CIBA-GEIGY AG (CH) 1982-06-30 EP disclosed
EP-0054515-A1 Reactive dyestuffs, their preparation and their use CIBA-GEIGY AG (CH) 1982-06-23 EP disclosed