SCHEMBL10482181

SCHEMBL10482181

Cc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1Cl

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 7/20 0.53
SLC6A4 P31645 7/20 0.53
KCNH2 Q12809 7/20 0.53
FFAR1 O14842 5/20 0.52
MEN1 O00255 1/20 0.51
TTR P02766 1/20 0.51
PPOX P50336 1/20 0.51
KMT2A Q03164 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 3/20 0.46
RAB9A P51151 1/20 0.46
MAPT P10636 2/20 0.43
LMNA P02545 1/20 0.43
ATM Q13315 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
PPARG P37231 1/20 0.41
PPARD Q03181 1/20 0.41
PPARA Q07869 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9373448 0.87 L3MBTL1 (0.52) HTR2ASLC6A4KCNH2FFAR1MEN1
SCHEMBL11095176 0.85 FFAR1 (0.65) HTR2ASLC6A4KCNH2FFAR1MEN1
SCHEMBL11095342 0.85 FFAR1 (0.55) HTR2ASLC6A4KCNH2FFAR1MEN1
SCHEMBL15384989 0.84 HTR2A (0.59) HTR2ASLC6A4KCNH2FFAR1MEN1
SCHEMBL10776065 0.84 FFAR1 (0.48) HTR2ASLC6A4KCNH2FFAR1MEN1
SCHEMBL10482242 0.82 FFAR1 (0.52) HTR2ASLC6A4KCNH2FFAR1MEN1
SCHEMBL10615136 0.82 FFAR1 (0.55) HTR2ASLC6A4KCNH2FFAR1MEN1
SCHEMBL8812673 0.82 L3MBTL1 (0.52) HTR2ASLC6A4KCNH2FFAR1MEN1
SCHEMBL10594849 0.82 MEN1 (0.70) HTR2ASLC6A4KCNH2FFAR1MEN1
SCHEMBL8684464 0.81 FFAR1 (0.61) HTR2ASLC6A4KCNH2FFAR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0338306-A2 Halogen-substituted phenoxybenzyl compounds BAYER AG (DE) 1989-10-25 EP disclosed