Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA4 | P22459 | 1/20 | 0.41 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.41 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10484170 | 1.00 | KCNA4 (0.41) | KCNA4KCNA1KCNAB1KMT2AMEN1 | |
| SCHEMBL15436882 | 0.78 | MEN1 (0.48) | KMT2AMEN1CYP2C19LMNAEPHX1 | |
| SCHEMBL3092749 | 0.78 | MEN1 (0.48) | KMT2AMEN1CYP2C19LMNAEPHX1 | |
| SCHEMBL3092739 | 0.78 | MEN1 (0.48) | KMT2AMEN1CYP2C19LMNAEPHX1 | |
| SCHEMBL1245102 | 0.78 | MEN1 (0.48) | KMT2AMEN1CYP2C19LMNAEPHX1 | |
| SCHEMBL15436881 | 0.78 | MEN1 (0.48) | KMT2AMEN1CYP2C19LMNAEPHX1 | |
| SCHEMBL877724 | 0.78 | MEN1 (0.48) | KMT2AMEN1CYP2C19LMNAEPHX1 | |
| SCHEMBL16796701 | 0.74 | DNMT3B (0.40) | KCNA4KCNA1KCNAB1KMT2AMEN1 | |
| SCHEMBL13356510 | 0.69 | MEN1 (0.48) | KMT2AMEN1CYP2C19LMNAEPHX1 | |
| SCHEMBL7145034 | 0.67 | KCNA4 (0.40) | KCNA4KCNA1KCNAB1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4829090-A | SECONDARY AMINES, ANTITUMOR | BURROUGHS WELLCOME CO. (US) | 1989-05-09 | — | — | US | disclosed |
| US-4810727-A | ANTITUMOR | BURROUGHS WELLCOME CO. (US) | 1989-03-07 | — | — | US | disclosed |
| US-4719048-A | ANTITUMOR | BURROUGHS WELLCOME CO. (US) | 1988-01-12 | — | — | US | disclosed |
| US-4719046-A | ANTITUMOR | BURROUGHS WELLCOME CO. (US) | 1988-01-12 | — | — | US | disclosed |
| EP-0125702-B1 | POLYCYCLIC AROMATIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1987-08-12 | — | — | EP | disclosed |
| EP-0125702-A2 | Polycyclic aromatic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-11-21 | — | — | EP | disclosed |