Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10484475 | 0.93 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTPOLBPKM | |
| SCHEMBL10484552 | 0.86 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTPOLBPKM | |
| SCHEMBL10484468 | 0.85 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTPOLBPKM | |
| SCHEMBL9634069 | 0.83 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPOLBPKM | |
| SCHEMBL9633444 | 0.83 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPOLBPKM | |
| SCHEMBL6232589 | 0.78 | ALDH1A1 (0.40) | ALDH1A1LMNAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL9635318 | 0.78 | LMNA (0.57) | ALDH1A1LMNAMAPTPOLBPKM | |
| SCHEMBL9634534 | 0.78 | HIF1A (0.52) | ALDH1A1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL10484490 | 0.76 | HIF1A (0.43) | ALDH1A1LMNAMAPTKMT2AKDM4E | |
| SCHEMBL10484434 | 0.74 | TDP1 (0.49) | ALDH1A1LMNAMAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4855396-A | BINDER/CHARGE AGENT IN ELECTROSTATOGRAPHIC TONER PARTICLES | EASTMAN KODAK COMPANY (US) | 1989-08-08 | — | — | US | disclosed |
| US-4837394-A | CHARGE CONTROL AGENTS | EASTMAN KODAK COMPANY (US) | 1989-06-06 | — | — | US | disclosed |