Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8372225 | 0.89 | ADRB2 (0.42) | LMNACYP2A6ADRB2SLC6A3SLC6A2 | |
| SCHEMBL8375284 | 0.89 | ADRB2 (0.42) | LMNACYP2A6ADRB2SLC6A3SLC6A2 | |
| SCHEMBL8373341 | 0.89 | ADRB2 (0.42) | LMNACYP2A6ADRB2SLC6A3SLC6A2 | |
| SCHEMBL8605978 | 0.89 | ADRB2 (0.42) | LMNACYP2A6ADRB2SLC6A3SLC6A2 | |
| SCHEMBL8375286 | 0.76 | ADRB2 (0.38) | LMNACYP2A6ADRB2MAPK1CA1 | |
| Iodide SCHEMBL7901726 | 0.75 | LMNA (0.53) | LMNACYP2A6ADRB2IDO1TSHR | |
| Iodide SCHEMBL9067569 | 0.73 | ACHE (0.50) | LMNACYP2A6IDO1TSHRTDP1 | |
| Iodide SCHEMBL10793574 | 0.71 | ESR1 (0.50) | LMNASLC6A3SLC6A2TSHRHIF1A | |
| 1,4-Dichlorobenzene SCHEMBL27654439 | 0.69 | LMNA (0.80) | LMNACYP2A6ADRB2SLC6A3SLC6A2 | |
| Bromide SCHEMBL7874765 | 0.69 | LMNA (0.53) | LMNACYP2A6ADRB2IDO1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4837392-A | Dry electrostatographic developer containing toner particles comprising a vinyl addition polymer containing a covalently bound quaternary phosphonium salt | EASTMAN KODAK COMPANY (US) | 1989-06-06 | — | — | US | disclosed |
| US-4837391-A | HEAT RESISTANCE, COMPATAIBILITY | EASTMAN KODAK COMPANY (US) | 1989-06-06 | — | — | US | disclosed |