Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496558 | 0.85 | MAPT (0.57) | MAPTMAPK1KDM4ETDP1KMT2A | |
| SCHEMBL10485804 | 0.84 | CYP1A2 (0.57) | MAPK1KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL10485735 | 0.82 | CACNA1G (0.48) | MAPTKMT2AALDH1A1MEN1TSHR | |
| SCHEMBL10485766 | 0.82 | USP2 (0.57) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL10485801 | 0.82 | POLB (0.53) | MAPTMAPK1KDM4EKMT2AALDH1A1 | |
| SCHEMBL10485538 | 0.81 | LMNA (0.55) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL26964384 | 0.81 | MAPK1 (0.54) | MAPTMAPK1KDM4ETDP1KMT2A | |
| SCHEMBL1496588 | 0.79 | MAPT (0.58) | MAPTMAPK1KDM4ETDP1KMT2A | |
| SCHEMBL12663858 | 0.79 | MAPT (0.58) | MAPTMAPK1KDM4ETDP1KMT2A | |
| SCHEMBL1496796 | 0.79 | MAPK1 (0.59) | MAPTMAPK1KDM4ETDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882330-A | 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-11-21 | — | — | US | disclosed |
| US-4806555-A | CARDIAC ARRHYTHMIA INHIBITOR | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0269383-A2 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-01 | — | — | EP | disclosed |