Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496562 | 0.85 | CYP1A2 (0.60) | CYP1A2MAPK1KCNH2CACNA1GNPC1 | |
| SCHEMBL10485773 | 0.84 | MAPT (0.54) | MAPK1ALDH1A1HSD17B10TSHRKMT2A | |
| SCHEMBL10485766 | 0.84 | USP2 (0.57) | CYP1A2NPC1ALDH1A1TSHRCDK4 | |
| SCHEMBL9922436 | 0.84 | CYP1A2 (0.59) | CYP1A2MAPK1KCNH2CACNA1GNPC1 | |
| SCHEMBL10485801 | 0.84 | POLB (0.53) | MAPK1ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL9922127 | 0.84 | CYP1A2 (0.59) | CYP1A2MAPK1KCNH2CACNA1GNPC1 | |
| SCHEMBL10485735 | 0.84 | CACNA1G (0.48) | KCNH2CACNA1GNPC1ALDH1A1TSHR | |
| SCHEMBL10485538 | 0.83 | LMNA (0.55) | ALDH1A1TSHRDRD4KMT2AMEN1 | |
| SCHEMBL21194 | 0.81 | CYP1A2 (0.60) | CYP1A2MAPK1KCNH2CACNA1GNPC1 | |
| SCHEMBL93836 | 0.81 | CYP1A2 (0.60) | CYP1A2MAPK1KCNH2CACNA1GNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4609735-A | HYPOTENSIVE, ANTIARRHYTHMIA | A. H. ROBINS COMPANY, INC. (US) | 1986-09-02 | — | — | US | claimed |
| US-4882330-A | 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-11-21 | — | — | US | disclosed |
| US-4806555-A | CARDIAC ARRHYTHMIA INHIBITOR | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0269383-A2 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-01 | — | — | EP | disclosed |
| US-4609735-A | HYPOTENSIVE, ANTIARRHYTHMIA | A. H. ROBINS COMPANY, INC. (US) | 1986-09-02 | — | — | US | disclosed |
| US-4538001-A | FROM 1-ARYLOXY-4-CHLORO-2-BUTANOL INTERMEDIATES; LOCAL ANESTHETICS, ANTIARRHYTHMICS, HYPOTENSIVES, BETA-ADRENERGIC BLOCKERS | A. H. ROBINS COMPANY, INC. (US) | 1985-08-27 | — | — | US | disclosed |
| US-4463190-A | FOR USE AS ADRENERGIC BLOCKING, HYPOTENSIVE, AND HYPOTENSIVE AGENTS; LOCAL ANESTHETIC | A. H. ROBINS COMPANY, INC. (US) | 1984-07-31 | — | — | US | disclosed |
| US-4379167-A | 1-Aryloxy-4-amino-2-butanols and the pharmaceutical use thereof | A. H. ROBINS COMPANY, INC. (US) | 1983-04-05 | — | — | US | disclosed |