Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10807772 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL10812065 | 0.88 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL10810824 | 0.85 | ACP1 (0.53) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL10810684 | 0.85 | ESR1 (0.47) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL10986183 | 0.85 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL11011950 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL8584061 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL7329771 | 0.81 | MAOA (0.58) | ALDH1A1CYP3A4TDP1SMN1; SMN2TP53 | |
| SCHEMBL10486590 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL10486553 | 0.80 | TNKS (0.61) | KDM4EMAPTKMT2ACYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4889941-A | Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase | FISONS CORPORATION (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0288077-A2 | Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase | PENNWALT CORPORATION (US) | 1988-10-26 | — | — | EP | disclosed |
| EP-0064165-B1 | ANTIHYPERTENSIVE AGENTS | PENNWALT CORPORATION (US) | 1987-06-10 | — | — | EP | disclosed |
| US-4668805-A | HYPOTENSIVE AGENTS | PENNWALT CORPORATION (US) | 1987-05-26 | — | — | US | disclosed |
| US-4495198-A | ELIMINATION OF BETA-BLOCKING ACTIVITY | PENNWALT CORPORATION (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0081621-A1 | Chromones | PENNWALT CORPORATION (US) | 1983-06-22 | — | — | EP | disclosed |
| EP-0064165-A1 | Antihypertensive agents | PENNWALT CORPORATION (US) | 1982-11-10 | — | — | EP | disclosed |