Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PPOX | P50336 | 1/20 | 0.46 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10714951 | 1.00 | KMT2A (0.51) | KMT2AEPHX2L3MBTL1LMNAPPOX | |
| SCHEMBL25577860 | 0.86 | L3MBTL1 (0.54) | KMT2AEPHX2L3MBTL1LMNAPPOX | |
| SCHEMBL5208842 | 0.86 | L3MBTL1 (0.54) | KMT2AEPHX2L3MBTL1LMNAPPOX | |
| SCHEMBL10487443 | 0.86 | KMT2A (0.55) | KMT2AEPHX2L3MBTL1LMNAALDH2 | |
| SCHEMBL25577858 | 0.86 | L3MBTL1 (0.54) | KMT2AEPHX2L3MBTL1LMNAPPOX | |
| SCHEMBL13744595 | 0.85 | KMT2A (0.53) | KMT2AEPHX2L3MBTL1LMNAALDH2 | |
| SCHEMBL15261678 | 0.83 | TSHR (0.43) | KMT2AL3MBTL1TSHRKDM4EMAPT | |
| SCHEMBL10022852 | 0.83 | EPHX2 (0.66) | KMT2AEPHX2L3MBTL1LMNAGAA | |
| SCHEMBL5204883 | 0.83 | EPHX2 (0.66) | KMT2AEPHX2L3MBTL1LMNAGAA | |
| SCHEMBL17710797 | 0.81 | TDP1 (0.56) | EPHX2GAATDP1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1015545-B | preparation method of glycolic acid derivative for treating diabetic complications | PFIZER (US) | 1992-02-19 | — | — | CN | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| CN-87100191-A | The hydroxy acid derivative of treatment diabetic complication | — | 1987-09-09 | — | — | CN | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |