Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10712640 | 0.93 | L3MBTL1 (0.51) | KMT2AL3MBTL1LMNAEPHX2GAA | |
| SCHEMBL13744595 | 0.89 | KMT2A (0.53) | KMT2AL3MBTL1LMNAEPHX2GAA | |
| SCHEMBL10714951 | 0.86 | KMT2A (0.51) | KMT2AL3MBTL1LMNAEPHX2GAA | |
| SCHEMBL10487407 | 0.86 | KMT2A (0.51) | KMT2AL3MBTL1LMNAEPHX2GAA | |
| SCHEMBL10022852 | 0.83 | EPHX2 (0.66) | KMT2AL3MBTL1LMNAEPHX2GAA | |
| SCHEMBL5204883 | 0.83 | EPHX2 (0.66) | KMT2AL3MBTL1LMNAEPHX2GAA | |
| SCHEMBL28285419 | 0.83 | AR (0.53) | KMT2ALMNASMN1; SMN2TSHRFFAR1 | |
| SCHEMBL5711747 | 0.81 | ALDH1A1 (0.47) | KMT2ALMNASMN1; SMN2TSHRFFAR1 | |
| SCHEMBL28914011 | 0.81 | SMN1; SMN2 (0.48) | KMT2AL3MBTL1LMNAEPHX2TDP1 | |
| SCHEMBL5209931 | 0.80 | TDP1 (0.67) | KMT2AL3MBTL1LMNAEPHX2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |