Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 14/20 | 0.57 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.57 |
| ▸ | ADRB3 known ✓ | P13945 | 18/20 | 0.54 |
| ▸ | ADRB1 known ✓ | P08588 | 12/20 | 0.54 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.48 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.48 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.48 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.48 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.48 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.48 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10706286 | 0.86 | ADRB2 (0.66) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488179 | 0.83 | ADRB2 (0.60) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488200 | 0.83 | ADRB2 (0.62) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488196 | 0.83 | ADRB2 (0.65) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488552 | 0.81 | ADRB2 (0.64) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488095 | 0.81 | ADRB2 (0.65) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488154 | 0.81 | ADRB2 (0.61) | ADRB2CHRM3ADRB3ADRB1 | |
| SCHEMBL10488114 | 0.80 | ADRB2 (0.62) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488131 | 0.80 | ADRB3 (0.71) | ADRB2CHRM3ADRB3ADRB1 | |
| SCHEMBL10488093 | 0.79 | ADRB2 (0.58) | ADRB2CHRM3ADRB3ADRB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853382-A | TREATING ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1989-08-01 | — | — | US | disclosed |
| US-4730008-A | STIMULANT FOR BETA-ADRENORECEPTORS | GLAXO GROUP LIMITED (GB) | 1988-03-08 | — | — | US | disclosed |