SCHEMBL10488248

SCHEMBL10488248

COc1c2ccccc2c(CNC(C)(CO)CO)c2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.47
ALDH1A1 P00352 2/20 0.47
MAPK1 P28482 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
CD274 Q9NZQ7 2/20 0.42
SLC2A1 P11166 2/20 0.40
CYP1A2 P05177 5/20 0.36
CYP2C9 P11712 1/20 0.36
IDO1 P14902 1/20 0.36
POLB P06746 1/20 0.36
LMNA P02545 3/20 0.36
CYP3A4 P08684 1/20 0.36
TSHR P16473 1/20 0.36
THPO P40225 1/20 0.36
STAT6 P42226 1/20 0.36
BLM P54132 1/20 0.36
NPBWR1 P48145 1/20 0.34
KMT2A Q03164 1/20 0.34
MCHR1 Q99705 1/20 0.34
PDCD1 Q15116 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10488879 0.98 ALDH1A1 (0.46) KDM4EALDH1A1MAPK1SMN1; SMN2CD274
SCHEMBL10488302 0.85 CD274 (0.38) ALDH1A1SMN1; SMN2CD274SLC2A1CYP1A2
SCHEMBL10488292 0.84 CD274 (0.39) KDM4EALDH1A1SMN1; SMN2CD274SLC2A1
SCHEMBL29449853 0.84 CD274 (0.40) ALDH1A1SMN1; SMN2CD274SLC2A1CYP1A2
Hydrochloric Acid SCHEMBL10488528 0.84 CD274 (0.38) ALDH1A1SMN1; SMN2CD274SLC2A1CYP1A2
SCHEMBL10488246 0.84 CD274 (0.40) ALDH1A1SMN1; SMN2CD274SLC2A1CYP1A2
SCHEMBL10488213 0.83 CYP1A2 (0.40) CD274SLC2A1CYP1A2TSHRNPBWR1
Hydrochloric Acid SCHEMBL10488206 0.82 CD274 (0.39) ALDH1A1SMN1; SMN2CD274SLC2A1CYP1A2
SCHEMBL10488277 0.82 SLC2A1 (0.39) SMN1; SMN2CD274SLC2A1CYP1A2CYP2C9
SCHEMBL9465733 0.82 CD274 (0.37) KDM4EALDH1A1SMN1; SMN2CD274SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0125702-B1 POLYCYCLIC AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1987-08-12 EP claimed
EP-0125702-A2 Polycyclic aromatic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1984-11-21 EP claimed
US-4803226-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-02-07 US disclosed
US-4803221-A Anthracene derivatives BURROUGHS WELLCOME CO. (US) 1989-02-07 US disclosed
US-4719047-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US disclosed
US-4719049-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US disclosed
EP-0125702-B1 POLYCYCLIC AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1987-08-12 EP disclosed
EP-0125702-A2 Polycyclic aromatic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1984-11-21 EP disclosed