Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10518348 | 0.93 | KDM4E (0.46) | LMNASMN1; SMN2KDM4EPOLBMAPK1 | |
| SCHEMBL10515892 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2KDM4EPOLBMAPK1CYP3A4 | |
| SCHEMBL10488969 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EPOLBMAPK1GAA | |
| SCHEMBL10488470 | 0.75 | SMN1; SMN2 (0.48) | LMNASMN1; SMN2KDM4ECSNK2A1GAA | |
| SCHEMBL3449342 | 0.74 | LMNA (0.51) | LMNASMN1; SMN2KDM4EHTTMAPK1 | |
| SCHEMBL10488636 | 0.73 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2KDM4EPOLBKCNH2 | |
| SCHEMBL10488646 | 0.73 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2POLBCSNK2A1GAA | |
| SCHEMBL10488490 | 0.72 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2POLBCSNK2A1GAA | |
| SCHEMBL10488586 | 0.70 | LRRK2 (0.47) | LMNAKDM4EHTTPOLBMAPK1 | |
| SCHEMBL166433 | 0.70 | TDP1 (0.58) | LMNASMN1; SMN2POLBKCNH2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4871737-A | 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-10-03 | — | — | US | disclosed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | disclosed |