Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449344 | 0.75 | TSHR (0.48) | LMNAKDM4EHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL10488441 | 0.74 | LMNA (0.47) | LMNAKDM4EHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL3449727 | 0.73 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2CYP1A2CYP2D6CNR1 | |
| SCHEMBL7459174 | 0.72 | LMNA (0.48) | LMNAKDM4EHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL3344759 | 0.72 | RXFP1 (0.52) | LMNAKDM4ESMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL20154914 | 0.71 | TLR8 (0.45) | LMNAKDM4ECYP3A4CYP1A2CYP2D6 | |
| SCHEMBL3448525 | 0.71 | CXCR4 (0.50) | LMNAKDM4ESMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL5479118 | 0.69 | CYP3A4 (0.45) | LMNAKDM4EHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL18172301 | 0.69 | PIM1 (0.44) | LMNACYP3A4CYP1A2CYP2D6TDP1 | |
| SCHEMBL4062438 | 0.69 | CYP3A4 (0.54) | LMNAKDM4ESMN1; SMN2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | LMNA 1717/4885KDM4E 3882/4885HTT 3861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.