Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CCR1 | P32246 | 2/20 | 0.48 |
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | CCR8 | P51685 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29531218 | 0.97 | — | — | |
| SCHEMBL15561907 | 0.97 | KDM4E (0.50) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL65664 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL29077445 | 0.95 | — | — | |
| SCHEMBL30065146 | 0.95 | — | — | |
| SCHEMBL28091796 | 0.95 | — | — | |
| Bromide SCHEMBL34472696 | 0.95 | KDM4E (0.48) | KDM4ELMNACCR1CCR5CCR8 | |
| Hydrochloric Acid SCHEMBL7736230 | 0.95 | KDM4E (0.48) | KDM4ELMNACCR1CCR5CCR8 | |
| Hydrochloric Acid SCHEMBL8914539 | 0.95 | — | — | |
| Fluoride SCHEMBL27811535 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4816595-A | OXIDATIVE CARBONYLATION OF ALCOHOLS | BRITISH PETROLEUM COMPANY P.L.C. (GB) | 1989-03-28 | — | — | US | disclosed |
| EP-0163442-B1 | PROCESS FOR THE PREPARATION OF ESTERS OF DICARBOXYLIC ACIDS | The British Petroleum Company p.l.c. (GB) | 1988-10-19 | — | — | EP | disclosed |
| US-4749816-A | Chemical process | BRITISH PETROLEUM CO. P.L.C. (GB) | 1988-06-07 | — | — | US | disclosed |
| EP-0254400-A1 | Process for the production of acetals or ketals | The British Petroleum Company p.l.c. (GB) | 1988-01-27 | — | — | EP | disclosed |
| EP-0220863-A1 | Preparation of carbonate esters | The British Petroleum Company p.l.c. (GB) | 1987-05-06 | — | — | EP | disclosed |
| US-4642374-A | Oxidative carbonylation to make dicarboxylic acid esters | THE BRITISH PETROLEUM COMPANY P.L.C. (GB) | 1987-02-10 | — | — | US | disclosed |
| WO-1985005356-A1 | CHEMICAL PROCESS | THE BRITISH PETROLEUM COMPANY P.L.C. (GB) | 1985-12-05 | — | — | WO | disclosed |
| EP-0163442-A1 | Process for the preparation of esters of dicarboxylic acids | The British Petroleum Company p.l.c. (GB) | 1985-12-04 | — | — | EP | disclosed |