Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29077445 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL7736230 | 1.00 | KDM4E (0.48) | — | |
| Hydrochloric Acid SCHEMBL10488703 | 0.98 | KDM4E (0.46) | — | |
| SCHEMBL29531218 | 0.97 | — | — | |
| SCHEMBL15561907 | 0.97 | KDM4E (0.50) | — | |
| SCHEMBL65664 | 0.97 | — | — | |
| Bromide SCHEMBL34472696 | 0.95 | KDM4E (0.48) | — | |
| SCHEMBL30065146 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL10488706 | 0.95 | KDM4E (0.48) | — | |
| SCHEMBL28091796 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111094272-B | Pharmaceutically acceptable salt and crystal form of OTR inhibitor and preparation method | 江苏恒瑞医药股份有限公司 | 2022-05-27 | — | — | CN | claimed |
| US-5629134-A | SOLVENT, ALKALI SOLUBLE RESIN, ACID GENERATOR, PYRIDINE SALT | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1997-05-13 | — | — | US | claimed |
| CN-220611264-U | Omeprazole chloride processing device | 济宁华能制药厂有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-111965280-B | Method for rapidly determining sugar mixing ratio of Dangshan pear syrup | 安徽农业大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-116326412-A | Method for regulating and controlling rhizosphere activating effect of apples | 北京农学院 | 2023-06-27 | — | — | CN | disclosed |
| CN-110627812-B | Heterocyclic compounds as TRK inhibitors | 北京诺诚健华医药科技有限公司 | 2022-10-11 | — | — | CN | disclosed |
| EP-3983074-A1 | PYRIDINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| CN-105121437-B | Coumarin derivative and method for treating cystic fibrosis, chronic obstructive pulmonary disease and misfolded protein matter illness | 发现生物医药公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-108251466-A | A kind of method of enzymatic clarification esomeprazole | 浙江京新药业股份有限公司 | 2018-07-06 | — | — | CN | disclosed |
| CN-105246887-B | Coumarin derivative and the method for treating hyperproliferative disease | 发现生物医药公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-107434802-A | A kind of preparation method of Esomeprazole sodium | 湖北朗昕生化药业有限公司 | 2017-12-05 | — | — | CN | disclosed |
| CN-107400118-A | The preparation method of esomeprazole intermediate | 信泰制药（苏州）有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-105418589-B | A kind of esomeprazole magnesium trihydrate preparation method for treating disease of digestive system | 青岛市中心医院 | 2017-09-26 | — | — | CN | disclosed |
| CN-103896916-B | A kind of preparation method of Esomeprazole sodium | 鲁南贝特制药有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103694223-B | A kind of one kettle way prepares the method for esomeprazole magnesium | 乐普药业股份有限公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-104797572-A | Pyridone derivatives as acid secretion inhibitors and process for preparing the same | KARUS THERAPEUTICS LTD | 2015-07-22 | — | — | CN | disclosed |
| CN-100436445-C | Pyrazole derivative | DAIICHI SEIYAKU CO (JP) | 2008-11-26 | — | — | CN | disclosed |
| CN-1902191-A | Amidopyrazole derivative | DAIICHI SEIYAKU CO (JP) | 2007-01-24 | — | — | CN | disclosed |
| CN-1759110-A | Pyrazole derivatives | DAIICHI SEIYAKU CO (JP) | 2006-04-12 | — | — | CN | disclosed |
| US-5629134-A | SOLVENT, ALKALI SOLUBLE RESIN, ACID GENERATOR, PYRIDINE SALT | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1997-05-13 | — | — | US | disclosed |