Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indomethacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 9/20 | 0.98 |
| ▸ | PTGS1 known ✓ | P23219 | 4/20 | 0.98 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.98 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.98 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.98 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.98 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.98 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | PTGES | O14684 | 1/20 | 0.98 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.98 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indomethacin SCHEMBL3518614 | 0.99 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL29525957 | 0.99 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL9300 | 0.99 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL29353712 | 0.99 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL23391006 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL8352438 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL6356562 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL1817813 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL22472310 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL23632959 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117946095-A | Indometacin prodrug compound activated by active oxygen as well as preparation method and application thereof | 东华大学 | 2024-04-30 | — | — | CN | claimed |
| EP-0047358-B1 | INDOL ACETIC DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | A. Nattermann & Cie. GmbH (DE) | 1984-09-19 | — | — | EP | claimed |
| EP-0047358-A1 | Indol acetic derivatives, process for producing the same and pharmaceutical compositions comprising the same | A. Nattermann & Cie. GmbH (DE) | 1982-03-17 | — | — | EP | claimed |
| CN-117946095-A | Indometacin prodrug compound activated by active oxygen as well as preparation method and application thereof | 东华大学 | 2024-04-30 | — | — | CN | disclosed |
| CN-111004167-B | Salts and prodrugs of 1-methyl-D-tryptophan | 新联基因公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-113501773-B | Beta-ketone sulfoxide derivative of carboxylic acid drugs and preparation method and application thereof | 宁夏大学 | 2022-07-01 | — | — | CN | disclosed |
| CN-113501773-A | Beta-ketone sulfoxide derivative of carboxylic acid drugs and preparation method and application thereof | 宁夏大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-108938710-B | Application of tobacco beans or extract thereof in preparation of medicine for treating and/or preventing arthritis | 澳门大学 | 2021-10-08 | — | — | CN | disclosed |
| CN-112939828-A | Beta-ketone sulfoxide derivative of carboxylic acid drugs and preparation method and application thereof | 宁夏大学 | 2021-06-11 | — | — | CN | disclosed |
| CN-111961043-B | Acetazolamide derivative, preparation method thereof and application thereof in preparation of drugs for treating coronary heart disease | 东南大学 | 2021-01-15 | — | — | CN | disclosed |
| CN-111961043-A | Acetazolamide derivative, preparation method thereof and application thereof in preparation of drugs for treating coronary heart disease | 东南大学 | 2020-11-20 | — | — | CN | disclosed |
| US-4464379-A | Indol acetic acid derivatives and anti-inflamatory and related uses thereof | A. NATTERMANN & CIE GMBH (DE) | 1984-08-07 | — | — | US | disclosed |
| US-4412994-A | AMINE COMPOUNDS CONTAINING THE ACYL RESIDUE OF INDOMETHACIN AS A SUBSTITUENT | INTERX RESEARCH CORPORATION (US) | 1983-11-01 | — | — | US | disclosed |
| US-4407804-A | SYNERGISTIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-10-04 | — | — | US | disclosed |
| US-4381307-A | Soft tertiary amine esters of bio-affecting carboxylic acids | MERCK & CO., INC. (US) | 1983-04-26 | — | — | US | disclosed |
| US-4362738-A | ANTIINFLAMMATORIES | DR. KARL THOMAE GMBH (DE) | 1982-12-07 | — | — | US | disclosed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | disclosed |
| EP-0047358-A1 | Indol acetic derivatives, process for producing the same and pharmaceutical compositions comprising the same | A. Nattermann & Cie. GmbH (DE) | 1982-03-17 | — | — | EP | disclosed |
| EP-0039051-A2 | Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1981-11-04 | — | — | EP | disclosed |
| US-4206220-A | N-/1-/P-CHLOROBENZOYL/-5-METHOXY-2-METHYL-3-INDOLYLACETYLOXY/-N,N -DIHYDROCARBYLAMINE | INTERX RESEARCH CORPORATION (US) | 1980-06-03 | — | — | US | disclosed |