Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11727816 | 0.79 | DPP4 (0.46) | DPP4ALDH1A1MAPK1SMN1; SMN2TP53 | |
| SCHEMBL6082482 | 0.76 | MAPK1 (0.55) | GPR35ALDH1A1MAPK1SMN1; SMN2MEN1 | |
| SCHEMBL11504756 | 0.74 | CYP3A4 (0.48) | DPP4ALDH1A1MAPK1SMN1; SMN2TP53 | |
| SCHEMBL5712798 | 0.74 | MEN1 (0.54) | DPP4GPR35ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL1706740 | 0.74 | GPR35 (0.46) | DPP4GPR35MRGPRX4MEN1KMT2A | |
| SCHEMBL6819863 | 0.74 | TTR (0.56) | NOTUMDPP4MRGPRX4ALDH1A1MAPK1 | |
| SCHEMBL21826618 | 0.73 | DPP4 (0.48) | DPP4MRGPRX4ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL10495703 | 0.73 | AKR1B1 (0.43) | GPR35MRGPRX4HPGD | |
| SCHEMBL5712792 | 0.73 | MEN1 (0.52) | NOTUMDPP4GPR35ALDH1A1MAPK1 | |
| SCHEMBL3695890 | 0.72 | HPGD (0.50) | ALDH1A1MAPK1SMN1; SMN2MEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4869913-A | DIETETICS | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-09-26 | — | — | US | disclosed |
| US-4522839-A | 3-Substituted 2,4,6-trihalogenated benzamides as sweetening agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-06-11 | — | — | US | disclosed |
| EP-0055689-B1 | 3-SUBSTITUTED 2,4,6-TRIHALOGENOBENZAMIDES AND THEIR SALTS, THEIR PREPARATION AND THEIR USE AS SUBSTITUTES FOR NATURAL SWEETENING AGENTS, AND SWEETENERS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-07-04 | — | — | EP | disclosed |
| US-4429152-A | DIABETES, DIETETICS | SCHERING, AKTIENGESELLSCHAFT (DE) | 1984-01-31 | — | — | US | disclosed |
| EP-0055689-A1 | 3-Substituted 2,4,6-trihalogenobenzamides and their salts, their preparation and their use as substitutes for natural sweetening agents, and sweeteners containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-07-07 | — | — | EP | disclosed |