Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23190953 | 0.83 | MAPT (0.59) | MAPTNPC1RAB9ACYP19A1LMNA | |
| SCHEMBL10405285 | 0.81 | CPT1B (0.41) | MAPTNPC1RAB9ACYP19A1LMNA | |
| SCHEMBL10405649 | 0.81 | PARP10 (0.44) | MAPTNPC1RAB9ACYP19A1LMNA | |
| SCHEMBL17591087 | 0.78 | MAPT (0.48) | MAPTNPC1RAB9ACYP19A1LMNA | |
| SCHEMBL14886367 | 0.78 | CES2 (0.67) | MAPTRAB9ALMNACES2CES1 | |
| SCHEMBL1888848 | 0.77 | CES2 (0.55) | MAPTNPC1RAB9ALMNACYP1A2 | |
| SCHEMBL14886374 | 0.76 | MAPT (0.72) | MAPTNPC1RAB9ALMNACES2 | |
| SCHEMBL11664895 | 0.76 | PARP10 (0.47) | MAPTNPC1RAB9ACYP19A1LMNA | |
| SCHEMBL10405628 | 0.74 | ALDH1A1 (0.71) | MAPTNPC1RAB9ALMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL28122115 | 0.74 | CES2 (0.52) | MAPTNPC1RAB9ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120558-B1 | ANTIHYPERTENSIVE N-PIPERAZINYLALKANOYLANILIDES | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1989-03-08 | — | — | EP | disclosed |