SCHEMBL1049895

SCHEMBL1049895

O=C(c1ccccc1)c1ccc(OCC(O)Cn2c(=O)n(CC(O)COc3ccc(C(=O)c4ccccc4)cc3)c(=O)n(CC(O)COc3ccc(C(=O)c4ccccc4)cc3)c2=O)cc1

nearest known ligand 0.68

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.68
ABCB1 P08183 12/20 0.67
SMN1; SMN2 Q16637 3/20 0.62
ALDH1A1 P00352 3/20 0.62
CYP2D6 P10635 1/20 0.62
CYP2C9 P11712 1/20 0.62
CYP2C19 P33261 1/20 0.62
LMNA P02545 3/20 0.60
HTT P42858 2/20 0.60
MAPT P10636 1/20 0.57
USP2 O75604 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13096315 0.94 MAPK1 (0.61) MAPK1ABCB1SMN1; SMN2ALDH1A1CYP2D6
SCHEMBL15672147 0.94 MAPK1 (0.61) MAPK1ABCB1SMN1; SMN2ALDH1A1CYP2D6
SCHEMBL14064868 0.87 LMNA (0.67) CYP2D6CYP2C9CYP2C19LMNAHTT
SCHEMBL15872188 0.86 MAPK1 (0.61) MAPK1ABCB1SMN1; SMN2ALDH1A1CYP2D6
SCHEMBL18543110 0.85 ABCB1 (0.71) MAPK1ABCB1SMN1; SMN2ALDH1A1CYP2D6
SCHEMBL19669063 0.84 PKM (0.59) ALDH1A1CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL14625832 0.82 ABCB1 (0.64) MAPK1ABCB1SMN1; SMN2ALDH1A1CYP2D6
SCHEMBL2384639 0.81 ABCB1 (0.66) MAPK1ABCB1SMN1; SMN2ALDH1A1CYP2D6
SCHEMBL11686021 0.80 LMNA (0.58) ALDH1A1CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL11680313 0.80 LMNA (0.58) ALDH1A1CYP2D6CYP2C9CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140199468-A1 NANOFIBERS CONTAINING LATENT REACTIVE GROUPS INNOVATIVE SURFACE TECHNOLOGIES, INC. (US) 2014-07-17 US claimed
US-8709809-B2 Nanofibers containing latent reactive groups INNOVATIVE SURFACE TECHNOLOGIES, INC. (US) 2014-04-29 US claimed
CN-110997746-B Photocrosslinked polymers for enhanced durability 心脏起搏器股份公司 2021-12-28 CN disclosed
EP-3668912-B1 PHOTOCROSSLINKED POLYMERS FOR ENHANCED DURABILITY CARDIAC PACEMAKERS INC (US) 2021-06-30 EP disclosed
US-10835638-B2 Photocrosslinked polymers for enhanced durability CARDIAC PACEMAKERS, INC. (US) 2020-11-17 US disclosed
CN-110997746-A Photocrosslinked polymers for enhanced durability 心脏起搏器股份公司 2020-04-10 CN disclosed
US-20190054204-A1 PHOTOCROSSLINKED POLYMERS FOR ENHANCED DURABILITY CARDIAC PACEMAKERS, INC. 2019-02-21 US disclosed
US-9833543-B2 Implantable scaffolds and methods of use INNOVATIVE SURFACE TECHNOLOGIES, INC. (US) 2017-12-05 US disclosed
US-9833543-B2 Implantable scaffolds and methods of use INNOVATIVE SURFACE TECHNOLOGIES, INC. (US) 2017-12-05 US disclosed
US-20140294783-A1 IMPLANTABLE SCAFFOLDS AND METHODS OF USE WEN JIE (US) 2014-10-02 US disclosed
US-20140294783-A1 IMPLANTABLE SCAFFOLDS AND METHODS OF USE WEN JIE (US) 2014-10-02 US disclosed
US-20100274012-A1 Photochemical Crosslinkers for Polymer Coatings and Substrate Tie-Layer INNOVATIVE SURFACE TECHNOLOGIES, INC. (US) 2010-10-28 US disclosed
US-7772393-B2 Photochemical crosslinkers for polymer coatings and substrate tie-layer INNOVATIVE SURFACE TECHNOLOGIES, INC. (US) 2010-08-10 US disclosed
US-7772393-B2 Photochemical crosslinkers for polymer coatings and substrate tie-layer INNOVATIVE SURFACE TECHNOLOGIES, INC. (US) 2010-08-10 US disclosed
US-20100081750-A1 Nanotextured Surfaces INNOVATIVE SURFACE TECHNOLOGIES, INC. 2010-04-01 US disclosed
US-20100081750-A1 Nanotextured Surfaces INNOVATIVE SURFACE TECHNOLOGIES, INC. 2010-04-01 US disclosed
EP-2160484-A2 NANOFIBERS CONTAINING LATENT REACTIVE GROUPS Innovative Surface Technologies, Inc. (US) 2010-03-10 EP disclosed
WO-2009002869-A2 NANOFIBERS CONTAINING LATENT REACTIVE GROUPS INNOVATIVE SURFACE TECHNOLOGIES, INC. (US) 2008-12-31 WO disclosed
US-20070003707-A1 Photochemical Crosslinkers for Polymer Coatings and Substrate Tie-Layer INNOVATIVE SURFACE TECHNOLOGIES, INC. 2007-01-04 US disclosed
US-20070003707-A1 Photochemical Crosslinkers for Polymer Coatings and Substrate Tie-Layer INNOVATIVE SURFACE TECHNOLOGIES, INC. 2007-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070003707-A1 Photochemical Crosslinkers for Polymer Coatings and Substrate Tie-Layer TIE1, LIG4, LIG3 MAPK1 3285/4885ABCB1 2783/4885SMN1; SMN2 4752/4885
US-20100274012-A1 Photochemical Crosslinkers for Polymer Coatings and Substrate Tie-Layer TIE1, LIG4, LIG3 MAPK1 3285/4885ABCB1 2783/4885SMN1; SMN2 4752/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.