SCHEMBL10499005

SCHEMBL10499005

COC[SiH2]C=Cc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.44
TUBB4A P04350 1/20 0.43
TUBB P07437 1/20 0.43
TUBA3C P0DPH7 1/20 0.43
TUBA1B P68363 1/20 0.43
TUBA4A P68366 1/20 0.43
TUBB4B P68371 1/20 0.43
TUBB3 Q13509 1/20 0.43
TUBB2A Q13885 1/20 0.43
TUBB8 Q3ZCM7 1/20 0.43
TUBA3E Q6PEY2 1/20 0.43
TUBA1A Q71U36 1/20 0.43
TUBA1C Q9BQE3 1/20 0.43
TUBB6 Q9BUF5 1/20 0.43
TUBB2B Q9BVA1 1/20 0.43
TUBB1 Q9H4B7 1/20 0.43
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
KDM4E B2RXH2 1/20 0.41
USP2 O75604 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14958526 0.81 RELA (0.46) TRPA1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2502927 0.79 KDM4E (0.38) TRPA1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1468386 0.72 TRPA1 (0.48) TRPA1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2841064 0.72 MAOB (0.44) TRPA1MEN1KMT2AALDH1A1MAPT
SCHEMBL1468384 0.72 TRPA1 (0.48) TRPA1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL21527926 0.72 MAOB (0.44) TRPA1MEN1KMT2AALDH1A1MAPT
SCHEMBL14957086 0.69 MAOB (0.41) TRPA1MEN1KMT2AALDH1A1MAPT
SCHEMBL5807431 0.69 MAOB (0.41) TRPA1ALDH1A1MAPTSMN1; SMN2NFE2L2
SCHEMBL15902563 0.69 MAOB (0.41) TRPA1ALDH1A1MAPTSMN1; SMN2NFE2L2
SCHEMBL1732811 0.69 ALDH1A1 (0.41) TRPA1MEN1KMT2AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4889904-A HEATING MIXTURE OF ALKOXY-FUNCTIONAL DISILANE AND EITHER ALKOXY-FUNCTIONAL SILANE WITH UNSATURATED SUBSTITUENT OR UNSATURATED HYDROCARBON DOW CORNING CORPORATION (US) 1989-12-26 US claimed
US-8871890-B2 Curable resin composition and cured article DAICEL CORPORATION (JP) 2014-10-28 US disclosed
EP-2636706-A1 CURABLE RESIN COMPOSITION AND CURED ARTICLE Daicel Corporation (JP) 2013-09-11 EP disclosed
US-20130131265-A1 CURABLE RESIN COMPOSITION AND CURED ARTICLE DAICEL CORPORATION (JP) 2013-05-23 US disclosed